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Week 5 of the NFL season is here, and we're starting to get a clearer picture of the NFL landscape. We've seen pretenders start hot and cool off soon after, we've seen some strong contenders start slow, and, of course, we've seen what injuries can do to a team's championship aspirations. Whatever the case may be, a handful of Week 5 games have seen notable line movement shifts ahead of the weekend. 

If you're interested in NFL betting, make sure to check out which games have seen lines move ahead of Sunday and Monday's action. Here, we dive into NFL Week 4 line movement, with odds courtesy of BetMGM Sportsbook, where new users can get up to $1,500 in bonus bets:

Texans at Ravens (1 p.m. ET)

  • Open: Baltimore -6.5, O/U 43.5
  • Now: Houston -1.5, O/U 40.5

Call this one the Lamar Jackson Effect. The star Ravens quarterback left Week 4 due to a hamstring injury while Baltimore was getting blown out in Kansas City, and while it seemed like this was maybe a case of a team keeping its star player as healthy as can be, it wound up being that Jackson is unlikely to play this week. Not only that, but he may miss multiple games due to injury. Cooper Rush is slated to start in Jackson's place.

Naturally, the betting line for this game changed dramatically. The Ravens are now 1.5-point underdogs at home after opening at -6.5, and the total is down to 40.5 from 43.5. The Texans have had one of the NFL's worst offenses, too, which also plays a role in the low total.

Broncos at Eagles (1 p.m. ET)

  • Open: Philadelphia -4.5
  • Now: Philadelphia -3.5

It's a bit surprising to see the Broncos enter Week 5 at 2-2, but narrow losses to Indianapolis and Los Angeles have Denver at .500 entering this battle with the Eagles, one of two undefeated teams left in the NFL. 

Denver has a great roster that is coming off a playoff season, while the Eagles are the reigning champs. Philly has looked mortal, despite the unbeaten record, as the Eagles have won each game by one score, just narrowly surviving each time out. Denver is now a 3.5-point underdog after opening at +4.5.

Dolphins at Panthers (1 p.m. ET)

  • Open: O/U 45.5
  • Now: O/U 44.5

The Dolphins will be without top receiver Tyreek Hill for the rest of 2025 after he suffered an ugly knee injury on Monday. That takes one of the NFL's premier playmakers away from an offense that, despite its star power, hasn't looked all that great amid a 1-3 start. The Panthers are also 1-3, and they may be without top running back Chuba Hubbard, who is nursing a knee injury. The total has dipped a point to 44.5 after opening at 45.5.

Titans at Cardinals (1 p.m. ET)

  • Open: Arizona -9.5
  • Now: Arizona -7.5

It says a lot more about the Titans than the Cardinals that Arizona opened at -9.5. Tennessee's offense has been, well, offensive in the early stages of 2025, with rookie Cam Ward and Co. failing to move the ball. 

Arizona is still a sizable favorite here, but the spread is now 7.5. That may be due in part to injuries, as the Cardinals can't catch a break in their backfield. After James Conner went down with a season-ending injury two weeks ago, the clear succession plan was for 2024 third-round pick Trey Benson to take over as lead back. That lasted a single week, as Benson is now heading to injured reserve, opening up opportunities for Emari Demercado, Michael Carter and Bam Knight.

Lions at Bengals (4:25 p.m. ET)

  • Open: Detroit -8.5
  • Now: Detroit -10.5

This matchup looked awesome on paper entering 2025, but it's far more lopsided now. The Bengals are without Joe Burrow for the foreseeable future, as the star quarterback suffered a bad toe injury in Week 2. His backup, Jake Browning, looked good in Week 2 but has struggled the last two games, both of which the Bengals have lost. Meanwhile, the Lions are winners of three in a row and have scored at least 34 points each of the last three weeks. Cincinnati's defense has looked vulnerable once again for most of 2025, so it's not too shocking to see things trending in Detroit's favor here.