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Jordan Mason RB | MIN
49ers' Jordan Mason: Cleared to face Tampa Bay
Mason (shoulder) doesn't have an injury designation for Sunday's game in Tampa Bay, Brianna Dix of the Buccaneers' official site reports.
Coming out of a bye week, Mason was a full practice participant Wednesday and Friday, sandwiched around a limited session Thursday. His time as a prime fantasy asset nonetheless seems to be nearing an end, with coach Kyle Shanahan saying Friday that only an unexpected late setback would prevent running back Christian McCaffrey (Achilles) from playing this Sunday. Mason may still get some snaps and touches but won't dominate carries the way he did for much of the past two months.
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Julius Chestnut RB | TEN
Titans' Julius Chestnut: Questionable for Week 10
Chestnut (foot) was limited in Friday's practice and is listed as questionable for Sunday's game against the Chargers.
Chestnut popped up on Thursday's injury report due to a foot issue, which limited him over the last two practices. If Chestnut cannot play Sunday, the Titans may elevate Jabari Small to serve as the No. 3 running back behind Tony Pollard and Tyjae Spears.
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Bucky Irving RB | TB
Buccaneers' Bucky Irving: Cleared to play Sunday
Irving (toe) doesn't have an injury designation for Sunday's game against San Francisco, Jennifer Lee Chan of NBC Sports Bay Area reports.
Irving has been playing through the injury for weeks, with Bucs coach Todd Bowles revealing that it's a recurring problem that dates back to college. It doesn't seem to have impacted the rookie much during games, and he did more in practice this week after managing just one limited session the week before.
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D'Ernest Johnson RB | TEN
Jaguars' D'Ernest Johnson: Questionable for Week 10
Johnson (hamstring) is listed as questionable ahead of Sunday's matchup against the Vikings.
Johnson likely sustained a hamstring injury during practice this week and is now in jeopardy of missing Jacksonville's Week 10 game. He practiced in a limited fashion both Thursday and Friday, but if he's unable to play through the issue Sunday, expect Travis Etienne and Tank Bigsby to handle all of the Jaguars' running back duties.
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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Listed as questionable, should play
McCaffrey (Achilles) is listed as questionable for Sunday's game at Tampa Bay, with coach Kyle Shanahan saying Friday that the running back will play, Eric Branch of the San Francisco Chronicle reports.
The 49ers will need to activate him from injured reserve by 4:00 p.m. ET on Saturday if he's indeed going to make his season debut this Sunday. Shanahan said Thursday that he expected McCaffrey to play, then reaffirming the plan after Friday's practice. McCaffrey may not jump right back into his accustomed every-down role, but even somewhat lesser usage could be enough to produce a big stat line against Tampa Bay's struggling defense.
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Tony Pollard RB | TEN
Titans' Tony Pollard: Cleared for Week 10
Pollard (foot) doesn't carry an injury designation for Sunday's game against the Chargers after returning to a limited practice Friday.
Fellow RB Tyjae Spears (hamstring) doesn't carry a Week 10 injury designation, either, and thus is set to return from a three-game absence. Pollard, who is coming off a 28-carry, 128-yard effort in a Week 9 overtime win over the Patriots, is on track to remain the Titans' lead back this weekend. The return of Spears should allow the team to ease Pollard's workload to a degree, but presumably not to an extent that would prevent him from maintaining fantasy utility versus Los Angeles.
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Dameon Pierce RB | PHI
Texans' Dameon Pierce: Won't face Detroit
Pierce (groin) has been ruled out for Sunday's game against the Lions.
Pierce will miss his second straight game, allowing Dare Ogunbowale and J.J. Taylor to handle backup duties behind workhorse Joe Mixon.
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Tank Bigsby RB | PHI
Jaguars' Tank Bigsby: Set for Week 10
Bigsby (ankle) doesn't have a designation for Sunday's contest against the Vikings.
Both Bigsby and Travis Etienne (hamstring) were limited in practice all week, but both running backs will be available to the Jaguars offense this weekend. During this past Sunday's defeat at Philadelphia, Bigsby earned 52 percent of the snaps en route to eight carries for 22 yards, while Etienne handled a 31 percent snap share and turned five touches into 30 yards from scrimmage. The breakdown between the pair should be somewhat similar Week 10.
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Travis Etienne RB | NO
Jaguars' Travis Etienne: Ready for Week 10
Etienne (hamstring) doesn't have a designation for Sunday's game versus the Vikings.
Both Etienne and Tank Bigsby (ankle) were limited in practice all week, but both running backs will be available to the Jaguars offense Week 10. During this past Sunday's loss at Philadelphia, Etienne earned a 31 percent snap share and had five touches for 30 yards from scrimmage, while Bigsby handled 52 percent of the snaps en route to eight carries for 22 yards. The breakdown between the two should be somewhat similar this weekend.
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James Conner RB | ARI
Cardinals' James Conner: Avoids injury designation
Conner (finger) doesn't have an injury designation for Sunday's game against the Jets, Bo Brack of GoPHNX.com reports.
Conner was a full practice participant Friday after limited showings the previous two days. He should be fine to handle his usual role, which entails the upside for 20-plus touches in close games. Conner has at least 10 touches in every game this season, including 21-plus in four of the past five weeks.