Saylors (back) is active for Sunday night's matchup with the Eagles.

Saylors will make his return to action after missing the team's win over Washington in Week 10 due to a back injury. The running back likely will be plugged back in as the Lions' primary kickoff returner against Philadelphia.

Vaki (ankle) is active for Sunday night's contest against Philadelphia.

Vaki is good to go after working through an ankle injury during the week at practice. With Craig Reynolds (coach's decision) inactive, Vaki will operate as the No. 3 option at running back behind Jahmyr Gibbs and David Montgomery in Week 11.

Reynolds (coach's decision) is inactive for Sunday night's contest against the Eagles.

Reynolds will be a healthy scratch for the second time this season after also having done so in Week 3 versus Baltimore. Detroit will roll with Jahmyr Gibbs, David Montgomery, Sione Vaki and Jacob Saylors at running back for Sunday Night Football.

Etienne rushed 19 times for 73 yards and two touchdowns and failed to bring in either of his two targets in the Jaguars' 35-6 win over the Chargers on Sunday.

Etienne was sharing plenty of work with Bhayshul Tuten (ankle) early on , but the latter ended up exiting the contest due to injury. That opened up more opportunity for Etienne, who contributed two- and 13-yard scoring runs for his first multi-TD game of the season. Etienne's yardage total was also his second highest since Week 4, and he could be in for a significant workload in a Week 12 road matchup against the Cardinals.

Mason rushed six times for 45 yards and a touchdown and wasn't targeted in Sunday's 19-17 loss to the Bears.

Mason didn't get many opportunities as the Vikings played catch-up for most of the game, so superior pass catcher Aaron Jones out-touched Mason 19-6. Mason made the most of his limited chances, breaking free for a 16-yard touchdown in the fourth quarter. With Jones operating as the top option in Minnesota's backfield heading into a Week 12 trip to Green Bay, Mason may not get many carries against the stout Packers run defense.

Cook rushed 16 times for 48 yards and secured all three targets for 66 yards in the Bills' 44-32 win over the Buccaneers on Sunday.

Cook unsurprisingly found running room at a premium against a stingy Buccaneers front, but he was able to salvage his fantasy day with his best work of the season as a receiver. The fourth-year pro contributed a 25-yard touchdown reception on his three catches, and he finished with a season-high receiving yardage total. The going doesn't get any easier for Cook in Week 12, however, as the Bills face a tough Texans defense on the road in a Thursday night matchup.

Monangai rushed 12 times for 23 yards and a touchdown while catching his only target for 14 yards in Sunday's 19-17 win over the Vikings.

Monangai scored a one-yard rushing touchdown to give the Bears a 7-3 lead in the second quarter, one play after setting up the goal-line opportunity with a powerful six-yard run to convert on third-and-4. He ceded most of the rushing opportunities to D'Andre Swift (21 carries for 90 yards) for the second straight game since Swift returned from a one-game absence due to a groin injury, but Monangai has scored a touchdown in both of those games. Monangai should continue to play a complementary role, including some short-yardage opportunities, in Week 12 against the Steelers.

McNichols turned four carries into 13 yards and added two catches on as many targets for 16 yards during the Commanders' 16-13 overtime loss to the Dolphins on Sunday.

Three of McNichols' six touches came in the fourth quarter of Sunday's game, though he was firmly entrenched as the Commanders' RB3 behind Chris Rodriguez and Jacory Croskey-Merritt. Through 11 regular-season games, McNichols has turned 26 carries into 181 yards and one touchdown while catching 15 passes (on 20 targets) for 139 yards.

Robinson rushed 23 times for 104 yards and two touchdowns and secured four of five targets for 39 yards in the Falcons' 30-27 overtime loss to the Panthers on Sunday.

Robinson put together a signature performance, recording four- and one-yard touchdown runs in the first half. Robinson's yardage marked his third occasion over the century mark this season, and his first multi-TD game on the ground as well. The third-year pro's carry total was also a new season high, affording him plenty of momentum heading into a Week 12 road matchup against the Saints. Robinson could be leaned on even more than usual in that game if Michael Penix (knee) is unavailable.

Jacobs' knee injury isn't believed to be season-ending, but he'll undergo additional testing Monday to determine the extent of the issue, Adam Schefter of ESPN reports.

After visiting the sideline tent in the first quarter of Sunday's eventual win at the Giants, Jacobs returned to action for a brief spell before the Packers ruled him out not long after halftime. He thus finished Week 11 action with seven carries for 40 yards while not catching his only target. No. 2 RB Emanuel Wilson took advantage of his touches, turning 12 into 49 yards from scrimmage and one rushing TD. Wilson and, to a lesser extent, Chris Brooks would stand to benefit if Jacobs misses any time.