NFL Player News

Breida has been ruled out of Sunday's game against the Cardinals due to an ankle injury, Matt Barrows of The Athletic reports.

The injury woes continue for Breida. After suffering a separated shoulder early in the the preseason slate, he served as the 49ers' top running back for the first two games. In the third, though, he sustained a hyperextended right knee. That issue plagued him before Week 4, when he again sustained a shoulder injury. He was active for Sunday's contest in a game-time decision, but then left early with yet another injury. The 49ers have a bit longer to prepare for their next game with a Monday night outing at Green Bay in Week 6. Alfred Morris would benefit most if Breida was finally forced to miss a game.

Henry rushed for 56 yards on 11 carries during Sunday's 13-12 loss to the Bills. He was targeted once, but did not record a catch.

Henry broke off his longest run of the season, bouncing off right tackle for 14 yards early in the second quarter. Despite leading the team in rushing yards and posting an improved 5.1 yards per rush, Henry has still to find the end zone this season. To make matters worse, he touched the ball 12 times in comparison to Dion Lewis' 15. While Henry's efficiency was improved, he hasn't surpassed 56 rushing yards in a game this season and doesn't have a lot of upside as a member of the low-powered Titans' offense.

McCaffrey carried 17 times for 58 yards Sunday against the Giants. He also caught five of six targets for an additional 35 yards and a touchdown in the 33-31 win.

After gashing the Bengals in his previous outing, McCaffrey struggled to the tune of just 3.4 yards per carry against a respectable Giants front. He was hardly involved as a pass catcher early on, but his workload in that regard picked up as the game went along and he scored his first touchdown of the season on an 18-yard reception in the fourth quarter. McCaffrey's usage varies quite a bit depending on game flow from week to week, but he's totaled at least 93 scrimmage yards in all four games this season and is averaging 6.8 receptions per outing. He'll look to build on this solid performance next Sunday against the Redskins.

Barkley told Jordan Raanan of ESPN.com after Sunday's 33-31 loss at Carolina that he "felt something in his back, not his knee or ankle" late in the contest.

At the conclusion of his second touchdown grab in the fourth quarter, Barkley took a big hit, per coach Pat Shurmur, but the nature of the injury wasn't known until Barkley himself spoke with the media. It doesn't appear serious at the moment, but the Giants are certain to provide a prompt update on Barkley's status with a short week to prepare for a Thursday night affair with the Eagles.

Breida was forced out of Sunday's game against the Cardinals with an ankle injury.

Prior to his exit, Breida had logged eight carries for 56 yards and turned his only target into a five-yard TD. Next up for the 49ers' carries while Breida is sidelined are Alfred Morris and Raheem Mostert.

Breida walked off the field during Sunday's game against the Cardinals, "slowly with some assistance," per Eric Branch of the San Francisco Chronicle. The running back was subsequently diagnosed with an ankle injury, Nick Wagoner of ESPN.com reports.

Next up for the 49ers' carries in the event that Breida ends up missing any time are Alfred Morris and Raheem Mostert.

Drake rushed six times for 46 yards and caught seven of 11 targets for 69 yards and a touchdown in Sunday's 27-17 loss to the Bengals.

Drake opened the scoring halfway through the second quarter with a 22-yard touchdown catch and was Miami's most productive receiving option across the board. The 24-year-old running back also looked explosive on the ground, but he got just six rushing attempts to Frank Gore's 13. Expect Gore to cut into Drake's production significantly once again when Miami hosts the Bears in Week 6.

Barkley, who had a monster game with four catches for 81 yards and two scores, to go along with 15 carries for 48 more yards, left the game with an apparent knee injury after scoring a go-ahead touchdown. According to ESPN's Jordan Raanan, Barkley was moving well after the game, and coach Pat Shurmur said he was fine.

We'll have to wait for confirmation that Barkley is indeed okay, but the early report is a good sign. Barkley is already one of the league's best backs in a pure football sense, and despite playing behind a poor offensive line, also a top-tier fantasy option.

Conner rushed 21 times for 110 yards and two touchdowns and brought in all four of his targets for 75 yards in the Steelers' 41-17 win over the Falcons on Sunday. He also fumbled once but it went out of bounds.

As expected, Conner thrived through the air against a Falcons defense that came in having allowed the most receptions to running backs in the NFL. However, he also ripped off 5.2 yards per tote on the ground, leading to his best rushing yardage haul since the opener versus the Browns. Conner now has at least three catches in each of the first five games, and Sunday's receiving yardage total served as a season high. While Le'Veon Bell will reportedly return to the team during the Week 7 bye, Conner's strong play helps keep the possibility of a trade of the holdout Pro Bowl running back conceivable. Conner will look to build on Sunday's effort against the Bengals in a Week 6 divisional showdown.

Mixon (knee) rushed for 93 yards on 22 carries and caught three of four targets for 22 yards and a touchdown in Sunday's 27-17 win over Miami.

Mixon was the only Bengals running back to get a carry in this one, suggesting the team is comfortable giving him all the work he can handle. He made a terrific adjustment with the ball in the air to get in position for an 18-yard receiving score on the first play of the fourth quarter, propelling a 24-0 Cincinnati run to close out the game. Mixon will be an appealing Week 6 play against the Steelers.