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Alexander Mattison RB | MIA
Vikings' Alexander Mattison: Four carries Sunday
Mattison had four carries for 25 yards in Sunday's loss at Green Bay.
Mattison played just eight snaps on offense. He continues to be productive when in the game (nine carries for 49 yards Week 1) but is going to have a limited backup role unless Dalvin Cook gets hurt. It's still possible that Mattison could emerge with a goal-line role.
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James Conner RB | ARI
Steelers' James Conner: Optimism with regard to knee injury
Per Jeremy Fowler of ESPN.com, "multiple teammates" believe that Conner's knee issue is not serious.
Fowler adds that "the overall sentiment in the locker room is (that Conner's) issue is manageable," while noting that the running back walked through the Steelers' locker room and seemed to be moving fine. While this encouraging context doesn't preclude Conner from missing some time, it appears as though the team won't lose him for long, which is a welcome bit of good news on a day in which it was revealed that QB Ben Roethlisberger will miss the rest of the season with an elbow injury.
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Manages 17 yards from scrimmage
Edmonds notched one carry for two yards and reeled in both targets for 15 yards during Sunday's 23-17 loss in Baltimore.
Edmonds' usage increased significantly from the season opener to this contest, primarily due to a left wrist injury suffered by David Johnson. Johnson missed one series entirely in the first half and shared reps with Edmonds upon his return, resulting in the latter boosting his offensive snap share from 11 percent Week 1 to 40 percent Sunday. Edmonds has yet to show much in 18 games as a pro, but a larger workload could be on the horizon if Johnson's wrist issue lingers.
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Nyheim Miller-Hines RB | NO
Colts' Nyheim Hines: Just 14 total yards Sunday
Hines had two carries for nine yards one one reception for five yards on two targets in Sunday's win over Tennessee.
Hines didn't get much work behind Marlon Mack, though he got more snaps on offense (13) than No. 3 running back Jordan Wilkins (10 snaps). However, Wilkins had 82 yards rushing on five carries. Hines is still the No. 2 running back, but his production will be volatile based on when he's needed in the passing game. Still, it's concerning that he has just six carries and six targets combined in the first two games with Jacoby Brissett under center.
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Corey Clement RB | ARI
Eagles' Corey Clement: Will miss at least one week
Clement (shoulder) underwent an MRI on Monday and is expected to miss one or two weeks, Ian Rapoport of NFL Network reports.
Clement suffered a shoulder injury on a kick return during the third quarter of Sunday's 24-20 loss to the Falcons. He did not return to the game but appears to only be managing a short-term injury. As long as Clement is forced to miss time, expect Miles Sanders to handle kick returns and Darren Sproles to take back punts.
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Mark Walton RB | MIA
Dolphins' Mark Walton: Three carries in loss
Walton recorded three carries for 16 yards during Sunday's 43-0 loss to the Patriots.
Walton also caught one of two targets for 12 yards. The Dolphins suffered a blowout loss for a second consecutive week, forcing the team to focus on downfield throws and abandon the running game early on. Of course, as the No. 3 option behind Kalen Ballage and Kenyan Drake, it's unlikely that Walton will see notable carries even if Miami manages to keep Week 3's contest against the Cowboys more competitive.
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James Conner RB | ARI
Steelers' James Conner: Getting tests on knee
Conner will have tests Monday to determine the severity of his knee injury, Ian Rapoport of NFL Network reports.
Conner's departure from Sunday's 28-26 loss to Seattle left Jaylen Samuels in the lead role at the end of the game. With Ben Roethlisberger in the process of determining if he needs elbow surgery, the already struggling Pittsburgh offense is facing serious issues ahead of a Week 3 tilt with the 49ers. Samuels averaged 47 snaps, 14 carries, four catches and 109.3 scrimmage yards over a three-game stretch late last season when Conner was out with a knee injury.
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Tony Pollard RB | TEN
Cowboys' Tony Pollard: Workload shrinks
Pollard carried the ball four times for 22 yards and caught his only target for three yards in Sunday's win over Washington.
With Ezekiel Elliott taking on his usual workload (25 total touches), there wasn't much left over for Pollard. He did find the end zone on a three-yard run in the third quarter while Elliott was getting a breather, but the touchdown was wiped out by a holding penalty. The fact that the Cowboys were comfortable using Pollard in the red zone is encouraging, but unless something happens to Elliott, the rookie's fantasy value will be minimal.
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Jeff Wilson RB | MIA
49ers' Jeff Wilson: Scores twice in victory
Wilson received 10 carries for 34 yards and two touchdowns in Sunday's 41-17 win over the Bengals.
Wilson was signed off the practice squad with Tevin Coleman (ankle) sidelined, and the second-year back immediately made his presence felt with his first career TDs. Matt Breida and Raheem Mostert did most of the damage between the 20s, while Wilson saw most of his work when the game was sealed in the fourth quarter, despite the game stats showing a nearly even split in workload. Wilson may prove to be the best option near the goal line after Sunday's showing, even if he is third on the depth chart in terms of carry volume heading into next week's matchup against the Steelers.