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Marlon Mack RB | ARI
Colts' Marlon Mack: Exits game with hand injury
Mack won't return to Sunday's game against the Jaguars after suffering a hand injury, Zak Keefer of The Athletic reports.
Prior to his exit, Mack had logged 14 carries for 109 yards and a TD. With Jordan Wilkins (ankle) already out Sunday, Jonathan Williams and Nyheim Hines will handle the Colts' backfield duties for the remainder of Sunday's contest.
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Nick Bawden RB | HOU
Lions' Nick Bawden: Suffers injury Sunday
Bawden (knee) is questionable to return to Sunday's game against the Cowboys.
Bawden popped up on the injury report with a foot injury Saturday, but, as evidenced by this news, seems to be dealing with a new issue. The 2018 seventh-round pick is the team's only fullback on the roster, so it's unclear how the offense will approach things while Bawden is sidelined.
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Raheem Mostert RB | LV
49ers' Raheem Mostert: Set for bigger role Week 11
Mostert (knee) is active for Sunday's contest against the Cardinals, Matt Maiocco of NBC Sports Bay Area reports.
Mostert is bumping up the depth chart temporarily with Matt Breida sidelined at least one game due to a low-ankle sprain. Working behind Tevin Coleman, Mostert will look to produce as he has previously this season, with his 5.5 yards-per-carry average translating well if he gets a healthy dose of runs. Meanwhile, Jeff Wilson also may get in the mix out of the 49ers' backfield.
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Zach Zenner RB | NO
Cardinals' Zach Zenner: Healthy scratch Sunday
Zenner (coach's decision) won't play in Sunday's showdown with the 49ers, Darren Urban of the Cardinals' official site reports.
Zenner played just 13 special teams snaps in last week's win over Tampa Bay and, as evidenced by this news, has become expendable on the roster. The Cardinals will roll with only Kenyan Drake and David Johnson as the running backs for the game.
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Matt Breida RB | SF
49ers' Matt Breida: Taking seat Sunday
Breida (ankle) is inactive for Sunday's game versus the Cardinals, Matt Maiocco of NBC Sports Bay Area reports.
Slated to miss 1-to-2 weeks due to a low-ankle sprain, Breida will see his first DNP of the campaign. Behind lead back Tevin Coleman, Raheem Mostert (knee) and Jeff Wilson are the candidates to take on Breida's usual role.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Unable to play Sunday
Wilkins (ankle) is inactive for Sunday's matchup against the Jaguars.
Wilkins will miss the first game of his two-year career. The depth running back has rushed 27 times for 165 yards this year while catching four of five targets for 27 yards. In Wilkins' stead, Nyheim Hines and Jonathan Williams are set to rotate in behind backfield-leader Marlon Mack.
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Royce Freeman RB | CHI
Broncos' Royce Freeman: May cede more work to Lindsay
Freeman is excepted to handle a smaller role than normal out of the backfield Sunday against the Vikings with the Broncos planning to feature Phillip Lindsay more prominently, Tom Pelissero of NFL Network reports.
Denver has deployed a fairly even distribution of the workload between Freeman and Lindsay all season, with the latter playing between 40 and 56 percent of the offensive snaps and topping out at 25 touches and the former handling snap shares between 47 and 63 percent and maxing out at 19 touches. Freeman (4.0 yards per carry) has been far less efficient on the ground than Lindsay (4.9 YPC), however, which could provide an explanation behind the Broncos' supposed plan to feature the Lindsay more Week 11. Freeman's fantasy utility this week was already capped due to a tough matchup against a Minnesota team that ranks in the top half of the NFL in both rushing defense and scoring defense, but the potential of him falling out of a timeshare arrangement diminishes his prospects further.
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Nick Bawden RB | HOU
Lions' Nick Bawden: Ready to roll
Bawden (foot) is active for Sunday's game against the Cowboys.
Bawden popped up on the injury report with a questionable tag Saturday, but it won't keep him out of the game. The second-year pro is the team's only fullback, and he'll pave the way for Ty Johnson and J.D. McKissic.
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Damien Williams RB | ARI
Chiefs' Damien Williams: Seemingly on track to play Monday
Williams (personal) rejoined the Chiefs in Mexico City and is expected to play Monday against the Chargers, Ian Rapoport of NFL Network reports.
After being excused from practice Friday to tend to a family matter, Williams was tagged with a questionable designation Saturday, implying some uncertainty about his ability to make the trip to Mexico. Rapoport's latest report suggests that Williams has at least temporarily taken care of the family matter, so the expectation is that he'll be ready to lead the Kansas City backfield. It's a welcome development for Williams' fantasy managers, who likely won't have to sweat out his status leading up to Monday's 8:15 p.m. ET kickoff.
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Kenyan Drake RB | GB
Cardinals' Kenyan Drake: Slated to start Sunday
Drake is expected to be the Cardinals' starting running back for Sunday's game at San Francisco, Ian Rapoport of NFL Network reports.
In his first game working with David Johnson last Sunday in Tampa Bay, Drake worked ahead of the long-time Cardinal and even got all the RB reps in the fourth quarter, finishing with 16 touches and 41 yards from scrimmage on a 64 percent offensive snap share. Meanwhile, Johnson had six, 10 and 43, respectively. On Friday, coach Kliff Kingsbury wouldn't commit to a starter between the pair and noted the backfield will be "by committee" Week 11, per Josh Weinfuss of ESPN.com, with packages planned for both running backs. Drake seemingly will get the first shot against a tough 49ers defense, but he and Johnson are slated to have roles throughout the contest.