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Ty Chandler RB | NO
Vikings' Ty Chandler: Will not return
Chandler is out for the remainder of Sunday's game against the Bears with a hand injury.
Chandler was active for just the second time in his rookie season Sunday. However, he still has not seen the ball on offense. He'll work to be back Week 6 against the Dolphins.
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Marlon Mack RB | ARI
49ers' Marlon Mack: Healthy inactive Week 5
Mack (coach's decision) is inactive for Sunday's Week 5 clash against the Panthers.
The veteran back garnered active status for the last two games but logged only a combined five special-teams snaps, and he'll now sit out altogether Sunday. In his stead, Tevin Coleman, who was promoted from the practice squad Saturday, will serve as the No. 3 running back behind Jeff Wilson and Jordan Mason against Carolina.
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Damien Harris RB | BUF
Patriots' Damien Harris: Injures hamstring Sunday
Harris (hamstring) won't return to Sunday's game against the Lions.
With Pierre Strong inactive Sunday, Rhamondre Stevenson will handle the Patriots' RB duties for the rest of the contest. Harris, who carried four times for 11 yards prior to his exit, will target a possible return to action in Week 6 against the Browns.
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Damien Harris RB | BUF
Patriots' Damien Harris: Exits game with hamstring injury
Harris (hamstring) was forced out of Sunday's game against the Lions with a hamstring injury.
Prior to his exit from the contest, Harris had carried four times for 11 yards. With Pierre Strong a healthy inactive Sunday, Rhamondre Stevenson is currently the Patriots' only available running back versus Detroit.
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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Big game despite injury scare
Barkley rushed the ball 13 times for 70 yards and a touchdown in Sunday's 27-22 win over the Packers. He added three receptions on six targets for 36 yards.
Barkley left the game briefly late in the third quarter with a shoulder issue, but he didn't miss a significant amount of time. Despite the scare, Barkley dominated work out of the backfield and delivered a few splash plays, highlighted by gains of 41 and 40 yards. He capped off his day with a game-winning two-yard plunge into the end zone with just over six minutes remaining in the final quarter. Barkley now has at least 100 total yards or a touchdown in four of five games on the campaign.
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Aaron Jones RB | MIN
Packers' Aaron Jones: Reaches 80 total yards
Jones carried the ball 13 times for 63 yards in Sunday's 27-22 loss to the Giants. He added two receptions for 17 yards.
Jones dominated touches out the backfield, out-carrying AJ Dillon 13-6. He regularly found room to run as both a rusher and pass catcher, ripping off several gains of at least seven yards. Even so, Jones was unable to replicate the efficiency he showed through the first four games of the season -- leaving him just shy of 100 total yards. Further hurting Jones' fantasy value is Green Bay's struggles on offense, as he has only two touchdowns on the season -- both of which came in Week 2 against the Bears.
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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Checks back into contest
Barkley (shoulder) was cleared to return to Sunday's game against the Packers in London, Jordan Raanan of ESPN.com reports.
After exiting with just over three minutes remaining in the third quarter with an apparent right shoulder injury, Barkley received some treatment in the locker room before returning for the Giants' ensuing drive. He immediately delivered an impressive 41-yard catch and run in his first snap back on offense, so fantasy managers may be able to breathe easy for now.
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Salvon Ahmed RB | CHI
Dolphins' Salvon Ahmed: Unable to play Sunday
Ahmed (back) is inactive for Sunday's contest with the Jets.
Ahmed logged limited practices Thursday and Friday with the injury, but he's still not ready to compete. In his absence, Myles Gaskin will operate as the team's No. 3 running back. Ahmed will work to return in Week 6 against the Vikings.
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Khalil Herbert RB | SF
Bears' Khalil Herbert: Likely back to No. 2 role Sunday
Herbert is welcoming David Montgomery (ankle) back to the lineup for Sunday's game in Minnesota, Jason Lieser of the Chicago Sun-Times reports.
Herbert took over for Montgomery when the latter hurt his ankle and knee in the first half of a Week 3 matchup with the Texans, combining for 42 touches for 270 yards from scrimmage and two rushing TDs the past two contests. With Montgomery available Sunday, though, Herbert likely will take a back seat in the Bears backfield, like he did Weeks 1 and 2, when he has limited to 15 touches for 84 total yards and a score on the ground.
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Pierre Strong Jr. RB | GB
Patriots' Pierre Strong: Inactive in Week 5
Strong is inactive for Sunday's game against the Lions.
With Strong inactive, Damien Harris and Rhamondre Stevenson will once again lead the Patriots' rushing attack in Week 5, while the team will have six wide receivers active against Detroit.