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Kenneth Gainwell RB | TB
Eagles' Kenneth Gainwell: Gains zero yards
Gainwell carried the ball once for zero yards and wasn't targeted with any passes in Sunday's win against Indianapolis.
Gainwell saw the field for just 11 offenses snaps, fewer even than fellow depth running back Boston Scott (13 snaps). Scott also received five touches compared to just one for Gainwell. Gainwell has now received just one carry in three of the last four weeks and hasn't carried the ball more than five times in any game this season.
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Devine Ozigbo RB | DET
Devine Ozigbo: Will likely play in Week 12
Ozigbo will likely be elevated from Denver's practice squad and be a part of the running back rotation in Week 12, Mike Klis of 9News Denver reports.
Ozigbo is currently on the Broncos' practice squad, but the veteran running back will likely be called up and active for a Week 12 matchup against the Panthers. The 26-year-old would be in line to handle duties behind presumed starter Latavius Murray and Marlon Mack. Ozigbo's opportunity in Denver's backfield comes on the heels of Melvin Gordon being waived by the Broncos on Monday. Recent trade acquisition Chase Edmonds is also slated to miss time with a high right-ankle sprain. Despite head coach Nathaniel Hackett's claim that Ozigbo will be a part of the running back rotation in Week 12, he will be extremely difficult to trust for fantasy purposes with limited opportunities on a struggling offense.
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Mike Boone RB | MIA
Broncos' Mike Boone: Could return after Week 12
Boone (ankle) could return from injured reserve following Week 12, Mike Klis of 9News Denver reports.
Boone is eligible to return from IR in Week 13 after recovering from an ankle injury suffered in Week 8. The veteran would be welcomed into a running back room that looks a bit different after the Broncos' recent moves. Denver waived Melvin Gordon on Monday, and their recent trade acquisition Chase Edmonds is slated to miss time with a high right-ankle sprain. One would expect Boone to carve out a role in this backfield behind Latavius Murray, who projects to be the starter going forward. Teammates Marlon Mack and practice-squad member Devine Ozigbo also figure to handle carries. Boone becomes an interesting add for fantasy managers looking to add depth to their roster, especially with the 27-year-old's pass-catching ability needed for a Broncos team that struggles to push the ball down the field.
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Raheem Blackshear RB | DET
Panthers' Raheem Blackshear: Gets two touches
Blackshear caught two of three targets for 14 yards in Sunday's 13-3 loss to the Ravens.
Blackshear played 11 offensive snaps but didn't get any carries behind D'Onta Foreman and Chuba Hubbard. He holds minimal value heading into Week 12's matchup versus the Broncos.
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Elijah Mitchell RB | PHI
49ers' Elijah Mitchell: Leads 49ers in rushing
Mitchell rushed the ball nine times for 59 yards in Monday's 38-10 win over Arizona.
Mitchell led the team in both rush attempts and yards while averaging an efficient 6.6 yards per attempt. All of those marks are deceiving however, as Mitchell had only one carry at halftime and saw the majority of his work when the game was a blowout and the outcome hardly in question. He remains the insurance to Christian McCaffrey, but Mitchell's volume on a weekly basis will be hard to rely upon.
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James Conner RB | ARI
Cardinals' James Conner: Touchdown saves inefficient effort
Conner rushed the ball 14 times for 42 yards and a touchdown in Monday's 38-10 loss to the 49ers. He added two receptions on five targets for 12 yards.
Conner joined the rest of the Cardinals' offense by turning in a fairly abysmal performance. However, he salvaged his stat line with a two-yard touchdown plunge late in the second quarter. Otherwise, his effort was highlighted by inefficiency and mistakes -- highlighted by a drop early in the second quarter that led directly to San Francisco's second touchdown of the game. With Arizona's running back depth chart extremely thin, Conner is likely to see all the volume he can handle, though that may not lead to standout production on a struggling team.
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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Busy as pass catcher
McCaffrey rushed the ball seven times for 39 yards in Monday's 38-10 win over the Cardinals. He added seven receptions on seven targets for 67 yards.
McCaffrey was bottled up on the ground and held under 40 rushing yards for the second consecutive game. He managed to salvage some fantasy value with his work as a pass catcher, as he finished second on the team in targets and tied for the lead in receptions. Given the blowout nature of the game, McCaffrey earned only four touches in the second half, which also cut into his production. Even so, he's now managed to top 100 total yards in two of his three games as a 49er.
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Isaiah Spiller RB | LV
Chargers' Isaiah Spiller: Remains primary backup
Spiller tallied four carries for 11 yards and also caught both of his targets for an additional 11 yards in Sunday's 30-27 loss to the Chiefs.
Sunday marked the biggest disparity in the platoon backup RB position as Spiller out-snapped Sony Michel 16-5, easily outgaining the veteran for the third straight game. The rookie hasn't done a whole lot with the extra opportunities, but it's likely he'll still be a factor when Joshua Kelley (knee) eventually returns off injured reserve.
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Darrynton Evans RB | BUF
Darrynton Evans: Bumps back down to practice squad
Evans reverted to the Bears' practice squad Monday, per the NFL's transaction log.
Evans was elevated from Chicago's practice squad for the second time this season ahead of Sunday's loss to Atlanta. However, the 24-year-old running back once failed to record an offensive statistic, as he played six of his eight snaps on special teams Week 11. Evans will now be eligible for one game-day activation before requiring a full spot on the active roster in order to suit up again for the Bears in 2022.
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Tyrion Davis-Price RB | GB
49ers' Tyrion Davis-Price: Healthy scratch again
Davis-Price (coach's decision) has been ruled inactive for Monday's game against the Cardinals.
Davis-Price saw his playing time fall off Week 8, and he will be a healthy scratch for the second game in a row. With the rookie sidelined, Christian McCaffrey, Elijah Mitchell and Jordan Mason will once again slot in as the 49ers' top three running backs Week 11. Davis-Price's next opportunity to suit up will come against the Saints on Sunday.