Knight is expected to take on a bigger workload out of the Cardinals backfield Sunday at Indianapolis, Adam Schefter of ESPN reports.

In the absences of James Conner (foot) and Trey Benson (knee) last Sunday against the Titans, Knight was third in the RB rotation behind Michael Carter and Emari Demercado, but Schefter specifically noted that Knight is in line to work in front of Carter in Week 6. Carter recorded 23 touches on a 73 percent snap share Week 5, while Demercado (three touches, 28 percent) and Knight (five touches, 16 percent) were well behind him. If Knight supplants Carter at the top of the depth chart, the former would be slated for significant increases in both touches and snaps.

Haskins is expected to lead the Chargers backfield Sunday against the Dolphins, with Kimani Vidal also slated to mix in, Mike Garafolo of NFL Network reports.

That said, offensive coordinator Greg Roman told Kris Rhim of ESPN.com on Thursday that the Chargers weren't planning on leaning on a lead back in Week 6 with Omarion Hampton (ankle) landing on injured reserve. Instead, Roman noted that Haskins and Vidal are both "gonna be big factors in the game, how it's gonna unfold from snap count standpoint...can go a bunch of different ways in that regard." Even if Haskins draws the start, both backs should contribute versus Miami as the team adjusts to being without Hampton for at least four weeks, with Garafolo suggesting that the running back's absence could extend beyond that timeframe. Meanwhile, Garafolo indicates that it's also possible that the Chargers add backfield depth ahead of the Nov. 4 trade deadline. Either way, Haskins and Vidal both represent lineup options for fantasy managers who had been leaning on Hampton or are otherwise looking for backfield help this week.

Hampton, who was placed on injured reserve Wednesday due to a left ankle injury, isn't expected to be out for the season but is on track to be sidelined for more than the four-game minimum, Mike Garafolo of NFL Network reports.

Earlier in the week, Chargers head coach Jim Harbaugh didn't provide many details about the injury Hampton sustained in the Week 5 loss to the Commanders, but the fact that the promising rookie is expected to need more than four weeks to make a full recovery points to him likely nursing a high-ankle sprain. A target date for Hampton's return has yet to be established, but because the Chargers have a bye coming up in Week 12, the team could be motivated to hold him out through that period to give him ample time to heal. Garafolo notes that Hassan Haskins is likely to serve as the Chargers' lead back Sunday in Miami while practice-squad signee Kimani Vidal also sees work, but Los Angeles is expected to be in the market for a running back ahead of the Nov. 4 trade deadline to compensate for the long-term injuries to Hampton and Najee Harris (Achilles).

McLaughlin is active for the first time this season in Sunday's game against the Jets in London, Aric DiLalla of the Broncos' official site reports.

A healthy inactive for Denver's first five games, McLaughlin will finally get the chance to make his 2025 debut as he suits up as the Broncos' No. 3 back behind J.K. Dobbins and RJ Harvey. In order to make room for McLaughlin on the gameday roster, the Broncos have elected to make fellow running back Tyler Badie inactive for the first time. Though McLaughlin totaled 572 yards from scrimmage over 16 games in 2024, the Broncos likely won't call on him to play more than a handful of snaps behind Dobbins and Harvey on Sunday.

Herbert (coach's decision) is inactive for Sunday's game against the Broncos in London.

After signing with the Jets last week, Herbert dressed as the Jets' No. 3 running back for this past Sunday's 37-22 loss to the Cowboys. He didn't see any playing time on offense in the loss but contributed on special teams, where he brought back one kickoff for 22 yards. With Kene Nwangwu (hamstring) set to play Sunday for the first time since Week 1, the Jets won't have a need for Herbert as depth at running back or as a kickoff returner.

The Buccaneers elevated Wright from the practice squad to the active roster Saturday, Scott Smith of the team's official site reports.

Wright was signed to the Bucs' practice squad Tuesday, and he'll be on the team's active roster for Sunday's home clash against the 49ers. He'll be expected to serve as the Buccaneers' RB3 behind Rachaad White and Sean Tucker due to the absences Bucky Irving (foot/shoulder) and Josh Williams (concussion). Wright last saw action in 2023 as a member of the Ravens, when he played in one regular-season game and played solely on special teams.

The Chargers elevated Hines from the practice squad to the active roster Saturday, Kris Rhim of ESPN.com reports.

Hines joined the Chargers' practice squad Tuesday, and his addition gives the team much-needed depth at running back after Omarion Hampton (ankle) was placed on injured reserve. Hines will likely be active against the Dolphins on Sunday, and if he plays, it will mark his first action since the 2022 season, when he appeared in 16 regular-season games between the Bills (nine) and the Colts (seven). Hines could serve in a return role on kickoffs and punts but might also see work out of the backfield behind Hassan Haskins and Kimani Vidal.

The Patriots elevated Jennings from the practice squad to the active roster Saturday.

It's Jennings first elevation from the practice of the season, and he's slated to serve as the Patriots' RB3 behind Rhamondre Stevenson and TreVeyon Henderson during Sunday's game against the Saints. Jennings logged 13 carries for 33 yards across three regular-season games with New England in 2024.

Homer (calf) is listed as questionable for Monday's game against the Commanders.

Homer started the season on injured reserve due to a calf injury that he suffered in preseason action in August. He was a full participant in practice this past week, but he would need to be activated from IR in order to have a chance at playing in Washington on Monday. Once he's cleared to return, Homer could be deployed on special teams as a returner while providing depth in the Bears' backfield.

Kamara (ankle), who is listed as questionable for Sunday's game against the Patriots, is expected to play, Adam Schefter of ESPN reports.

Kamara told Matthew Paras of The New Orleans Times-Picayune that he injured his ankle in last Sunday's win over the Giants, which left him limited in practice Wednesday through Friday. Ultimately, Kamara's status for Sunday's contest will be confirmed about 90 minutes before a 1 p.m. ET kickoff, but even if he's active, there's a chance he cedes some snaps to his primary backup, Kendre Miller.