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Kyler Murray QB | MIN
Cardinals' Kyler Murray: Looks to be trending toward absence
Murray (hamstring), who is listed as questionable for Monday's game against the 49ers in Mexico City, appears unlikely to play, Ian Rapoport of NFL Network reports.
Josina Anderson of CBS Sports further supports Rapoport's report, noting that Colt McCoy will "definitively" start Monday, with the Cardinals having known since last week that Murray wasn't on track to play. After sitting out last week's win over the Rams with a hamstring injury, Murray took part in practices Thursday through Saturday, though merely as a limited participant. The Cardinals seemingly want to see him put in a full practice -- or at least get more practice reps under his belt -- before clearing him for game action. Expect Murray to be included on the team's inactive list, which will be released approximately 90 minutes before Monday's 8:15 p.m. ET kickoff. With McCoy on tap for another start, third-stringer Trace McSorley will serve as his backup for the second week in a row. Murray presumably will set his sights on a return to the lineup in Week 12 against the Chargers back in Arizona.
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Patrick Mahomes QB | KC
Chiefs' Patrick Mahomes: Clutch in SNF victory
Mahomes completed 20 of 34 pass attempts for 329 yards and three touchdowns while adding 23 rushing yards on four attempts in Sunday's 30-27 win over the Chargers.
Mahomes was in rare form against a talented Chargers secondary despite missing top wideouts JuJu Smith-Schuster (concussion) and Mecole Hardman (abdomen). He also lost fill-in starter Kadarius Toney early in the contest to a hamstring injury, which makes Mahomes' robust stat line even more impressive all things considered. Mahomes fortunately did not lose the services of Travis Kelce, as the dynamic duo connected for three more scores amidst an already dominant campaign. Mahomes has not experienced any sort of dip in production sans Tyreek Hill in 2022, boasting 10-game totals of 3,265 passing yards and 28 touchdowns that are right on par with his dominant career norms. Mahomes and the Chiefs will take on a reeling Rams squad next Sunday.
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Justin Herbert QB | LAC
Chargers' Justin Herbert: Excels in loss
Herbert tallied 23 completions on 30 attempts for 280 yards, two touchdowns and one interception in Sunday's 30-27 loss to the Chiefs. He also carried the ball five times for 17 yards.
Herbert set season highs in completion percentage and yards per completion, but the sterling outing wasn't enough to help the Chargers pull off the win. Sunday marked the first time since Week 7 the third-year signal caller tallied multiple touchdowns in a contest, and not coincidentally Sunday also marked the return of his two top targets in Keenan Allen and Mike Williams, although the latter didn't make it through the full game after sustaining an ankle injury. At the moment, Herbert is on pace for career lows in touchdowns and rushing yards, but most of that can be explained away with the injuries to his pass catchers and the rib injury he suffered near the end of September. The Pro Bowl quarterback should be poised for an intriguing stretch with matchups against the porous defenses of the Cardinals, Raiders and Dolphins over the next three weeks.
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Kirk Cousins QB | LV
Vikings' Kirk Cousins: Pulled in blowout loss
Cousins completed just 12 of 23 pass attempts for 105 yards while losing a fumble in Sunday's 40-3 blowout loss to Dallas.
Cousins was harassed by the Cowboys pass rush from start to finish, resulting in seven sacks for a collective loss of 49 yards Sunday. The offensive line stood no chance against Micah Parsons and company, and the team lost starting left tackle Christian Darrisaw (concussion) to add insult to literal injury. Cousins was pulled for the fourth quarter of this lopsided loss, and Nick Mullens finished the contest with the rest of the backups. Things won't get any easier for the veteran Cousins with a short week on tap against a tough Patriots defense Thursday. The silver lining for fantasy managers is that the Thanksgiving game will be an indoor home matchup as opposed to a late-season game in harsh conditions at Foxborough.
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Dak Prescott QB | DAL
Cowboys' Dak Prescott: Nearly perfect in blowout win
Prescott completed 22 of 25 pass attempts for 276 yards and two touchdowns in Sunday's 40-3 win over Minnesota. He added 16 rushing yards on three carries.
Prescott was flawless against a passing defense that has troubled other quarterbacks at times this season. This was the 29-year-old's strongest showing in 2022 since returning from thumb surgery, which bodes well for fantasy managers who have been underwhelmed through 10 weeks. Prescott could have had an even bigger game if the starters weren't pulled for the entire fourth quarter, a coaching decision influenced by the combination of a lopsided score and an upcoming short week. The Cowboys' franchise quarterback will look to build off this strong showing in a pivotal NFC East matchup against the Giants on Thanksgiving.
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Derek Carr QB | NO
Raiders' Derek Carr: Dices up Denver in win
Carr completed 23 of 37 passes for 307 yards, two touchdowns and no interceptions in Sunday's 22-16 win over the Broncos.
Carr continued to attempt throws at a high volume, as he has now taken to the air at least 36 times in each of his last three games. However, he posted one of his more efficient performances in Sunday's win, highlighted by touchdown throws of 35 and 31 yards to Davante Adams. Carr also managed to top 300 passing yards for the second time this season, powered by a campaign-best seven completions of 20 yards or more. Overall, he's thrown for multiple touchdowns and a minimum of 248 yards in each of the last three weeks.
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Kenny Pickett QB | CAR
Steelers' Kenny Pickett: Connects with Pickens in loss
Pickett completed 25 of 42 passes for 265 yards and a touchdown in Sunday's 37-30 loss to the Bengals. He added two rushing attempts for 14 yards.
Pickett found George Pickens for a 24-yard touchdown to tie the score at 17 in the second quarter. The pair of rookies have shown good chemistry from the get-go, so Pickett-to-Pickens could be a common phrase around Pittsburgh for years to come if the rookie quarterback proves capable of holding down the starting job. Two of Pickett's three career touchdown passes have been thrown to Pickens, but those three touchdowns have been accompanied by eight interceptions, as Pickett's still learning how to limit turnovers heading into a Week 12 primetime game in Indianapolis on MNF.
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Russell Wilson QB | NYG
Broncos' Russell Wilson: Efficient in loss
Wilson completed 24 of 31 passes for 247 yards, no touchdowns and no interceptions in Sunday's 22-16 loss to the Raiders. He added one rush for eight yards.
Wilson has produced varying degrees of efficiency this season, though he put together a strong performance in that regard by averaging 8.0 yards per attempt. However, his fantasy production remained uninspiring due to his lack of touchdowns, and he still has tallied multiple touchdowns in only one game this season. More positively, after topping 240 passing yards only once in his first four contests, Wilson has topped that mark in four of his last five matchups.
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Joe Burrow QB | CIN
Bengals' Joe Burrow: Tosses four touchdowns
Burrow was superb Sunday against the Steelers, completing 24 of 39 passes for 355 yards and four touchdowns. He did throw two tipped interceptions and was sacked twice.
If there was a downside to Burrow's performance, it's that too many passes got tipped at the line of scrimmage, leading to the two turnovers. But he overcame that to lead the Bengals on multiple long scoring drives, connecting for over 20 yards with six different pass catchers. A tough road matchup awaits at Tennessee, where Burrow was sacked nine times in the playoffs last season.
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Jared Goff QB | DET
Lions' Jared Goff: Not asked to do much in win
Goff completed 17 of 26 pass attempts for 165 yards and no touchdowns or turnovers in Sunday's 31-18 win over the Giants.
Detroit was carried by its three-headed rushing attack -- which combined for 150 yards and four touchdowns -- resulting in a low-volume fantasy game from Goff in an upset win over the now 7-3 Giants. The 2016 first overall pick has done a better job of protecting the football with just one interception over his last four games after turning the ball over nine times in his first six. Goff should be continued to be treated as a fringe starting option in standard formats heading into a Week 12 matchup against the Bills on Thursday.