Darnold completed 28 of 34 pass attempts for 341 yards, four touchdowns and one interception in Sunday's 38-35 loss to the Buccaneers.

Darnold's untimely interception in the closing moments of Sunday's narrow loss could not erase the gaudy passing numbers he provided fantasy managers Sunday. It was the 28-year-old's first start this season eclipsing the 300-yard mark in passing, and the most comfortable he has looked running Seattle's offense through five starts. Darnold will attempt to combine strong results with a Seahawks win in a road matchup against the Jaguars next Sunday.

Smith completed 25 of 36 passes for 228 yards with no touchdowns and two interceptions while adding three carries for eight yards in the Raiders' 40-6 loss to the Colts on Sunday.

The left half of Smith's stat line looked perfectly acceptable, but the two picks, four sacks and quarterback rating of 18.9 that comprise the rest of his numbers all underscore how difficult the afternoon was. The Raiders' day actually started off in encouraging fashion via a marathon 16-play, 80-yard drive that consumed 9:50 of the first quarter, but that ultimately culminated in a field goal. The next five possessions would feature a blocked punt, both of Smith's interceptions, a punt and a missed field goal, helping dig Las Vegas into a hole it couldn't recover from. Smith has now thrown nine interceptions over his first five games at the helm of the Raiders' offense, including three contests in which he's tossed multiple picks. Nevertheless, Smith will continue under center, potentially without Brock Bowers (knee) once again, when the Raiders welcome in the Titans for a favorable Week 6 home clash.

Daniels completed 15 of 26 pass attempts for 231 yards and a touchdown while rushing for 39 yards on eight attempts in Sunday's 27-10 win over the Chargers.

Daniels returned from a two-week absence due to a knee injury in order to lead his team to its third win of the season. The 24-year-old was sporting a brace on his left knee, but it did not appear to limit the quarterback's mobility on any of his eight carries Sunday. Daniels is averaging 221.3 passing yards and 41.3 rushing yards with four touchdowns to no interceptions in three 2025 starts. The dual-threat sophomore could be primed for his finest fantasy outing under the bright lights of Monday Night Football in Week 6 when the Commanders host a Bears defense that is surrendering 389.0 yards of offense to opponents this season.

Young completed 19 of 30 passes for 198 yards with two touchdowns and one interception while adding three carries for one yard in the Panthers' 27-24 win over the Dolphins on Sunday. He also lost a fumble.

Carolina managed to pull off a comeback from a 17-0 deficit, but Young had an uneven day that included three sacks in addition to his two turnovers. Rico Dowdle also helped carry the offense with his 206-yard, one-touchdown effort, but Young played a key part with a seven-yard touchdown pass to Xavier Legette that kickstarted the rally late in the first half, and he added a four-yard toss to Mitchell Evans that proved to be the game-winning score. Young has thrown for under 200 yards in all but one game this season, so even with the encouraging team result for the Panthers on Sunday, he remains a somewhat shaky fantasy option even in a favorable Week 6 home matchup against the Cowboys.

Nix completed 24 of 39 passes for 242 yards with a touchdown and no interceptions while adding three rushes for 22 yards in the Broncos' 21-17 win over the Eagles on Sunday. He also threw a two-point conversion pass.

Nix had his fair share of struggles against the Eagles' talented defense, but he helped lead Denver back from a 17-3 second-half deficit. Nix led a trio of fourth-quarter scoring drives, capping one of them with an 11-yard touchdown pass to Evan Engram and following it up with a two-point conversion toss to Troy Franklin. Nix has at least one touchdown pass in every game thus far this season and has posted his two highest passing yardage totals of the campaign in the last pair of contests heading into a Week 6 trip across the pond to face the Jets in London.

Tagovailoa completed 27 of 36 passes for 256 yards with three touchdowns and no interceptions and added one rush for five yards in the Dolphins' 27-24 loss to the Panthers on Sunday.

Tagovailoa managed well in his first game without Tyreek Hill (IR, knee), focusing a majority of his attention, as expected, on the trio of Jaylen Waddle, Darren Waller and De'Von Achane. The three pass catchers were responsible for Tagovailoa's three TD tosses and 17 of his completions overall. The 2020 first-round pick has multiple touchdown passes in four straight games -- and Sunday's tally was a season high -- but with Miami at 1-4, the overall long-term outlook for the Dolphins is bleak. A Week 6 home matchup against the Chargers could be an uphill battle for the short-handed offensive unit as well, even when factoring in Los Angeles' struggles against the Commanders in Week 5.

Mayfield completed 29 of 33 pass attempts for 379 yards and two touchdowns while rushing five times for 15 yards in Sunday's 38-35 win over the Seahawks.

Mayfield flirted with perfection in a masterful performance that saw him miss just four pass attempts while committing zero turnovers. The 30-year-old was especially sharp in the clutch when he led a pair of five-play drives that took up a little over one minute of game clock to give Tampa Bay the 10 points needed to secure victory. The loss of star WR Mike Evans (hamstring) hasn't hampered Mayfield and the passing offense, as the signal-caller is averaging 334.0 passing yards with a pair of touchdowns in the two games sans Evans. Mayfield will look to build off of the momentum of his cleanest outing when the Buccaneers host the 49ers next Sunday.

DeVito (coach's decision) is inactive for Sunday's game against the Bills and will serve as the emergency third quarterback.

As the emergency third quarterback, DeVito will not be allowed to see the field unless Drake Maye and Joshua Dobbs were to leave the game due to injury, illness or ejection.

Jones completed 20 of 29 passes for 212 yards with two touchdowns and no interceptions and added one rush for two yards in the Colts' 40-6 win over the Raiders on Sunday. He also committed a fumble recovered by Indianapolis.

Jones' solid, efficient stat line was a fitting microcosm of what's come to define his body of work early in his Colts tenure, as the veteran signal-caller once again turned in a mistake-free effort that complemented the exploits of Jonathan Taylor and the defense perfectly. Jones worked with a tight circle of five targets overall, tossing his pair of touchdowns to Tyler Warren (11 yards) and Michael Pittman (four yards). Jones has completed a sharp 71.3 percent of his passes and posted a 6:2 TD:INT through his first five games at the helm of Indianapolis' offense, and he's added another three scores on the ground. Jones next takes aim at the Cardinals' defense in a Week 6 home clash.

Murray (foot) returned to Sunday's game versus the Titans, Adam Schefter of ESPN reports.

Murray made a brief exit in the third quarter due to a foot injury but was able to get back on the field in short order. He'll look to build upon the 194 yards on 19-for-25 passing and 25 yards and a TD on four carries that he'd put together at the time of his departure.