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0:27Deebo Samuel Agrees to 1-Year Deal with 49ers
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1:36Gibbs, Robinson Not Practicing Amid Contract Talks
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1:06Kubiak's Offense to Rejuvenate Bowers & Jeanty
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0:53Texans Looking to Revitalize Offensive Line
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1:32Jerry Jones Would Give Up Future for Right Player
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1:47How Well Does the Cowboys' Revamped Defense Come Together?
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1:58Can QB Tyler Shough Elevate the Saints' Offense?
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1:44Kyler Murray vs J.J. McCarthy: Vikings QB Battle
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1:46Joe Brady Era Begins in Buffalo
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9:08One Reason For Optimism For Every NFC West Team
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10:18NFC West: Position Battles to Watch
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11:10Biggest Questions Before Camp: NFC West
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1:58NFL Win Totals: Can Dolphins Exceed Expectations?
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1:59What Else Do The Patriots Need?
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1:4249ers vs. Rams: Must-Watch For Week 1
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1:48NFC South Top 100: Atlanta Falcons Breakdown
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1:36NFC South Top 100: Only One Saint Makes List
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1:40Breaking Down 49ers in Prisco's 2026 Top 100
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1:58Six Seahawks Make Pete Prisco's Top 100 Players of 2026
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1:50Breaking Down Rams in Prisco's 2026 Top 100
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2025 Rushing
| STATS |
ATT
Rushing Attempts
|
YDS
Rushing Yards
|
AVG
Average Yards per Rush
|
TD
Rushing Touchdowns
|
LNG
Longest Rush
|
FL
Fumbles Lost
|
|---|---|---|---|---|---|---|
| Regular Season | — | — | — | — | — | — |
Top Isaac Guerendo News
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49ers' Isaac Guerendo: Placed on PUP list
The 49ers placed Guerendo (pectoral) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Guerendo is still recovering from a torn pectoral he suffered while lifting earlier in the offseason. While the 26-year-old will be unable to practice for now, he is expected to return at some point before the end of training camp.
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49ers' Isaac Guerendo: Dealing with torn pectoral
Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports.
The running back suffered the injury while lifting "about a month ago," per David Lombardi of SFStandard.com. Guerendo is expected back near the end of training camp, though he did already undergo surgery, per Jeremy Fowler of ESPN.com. The 2024 fourth-round pick did not receive a single carry in 2025 despite appearing in 14 regular-season games.
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49ers' Isaac Guerendo: Falls out of favor in 2025
Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.
Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robinson (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.
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49ers' Isaac Guerendo: Healthy scratch again in Week 17
Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.
Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.
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49ers' Isaac Guerendo: Inactive for MNF
Guerendo (coach's decision) is inactive for Monday night's game against the Colts.
Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.
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49ers' Isaac Guerendo: Role remains marginalized
Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans.
Guerendo remained a non-factor on offense behind Christian McCaffrey and Brian Robinson on San Francisco's running back depth chart. The 25-year-old Guerendo once returned kickoffs for the 49ers, but the team has removed him from that role completely since Week 5. Barring a string of catastrophic injuries in the backfield, Guerendo can safely be ignored during the fantasy playoffs.
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Player Bio
| HT/WT: 6-0, 221 lbs |
| Birthplace: Clayton, IN |
| Age: 26 |
| School: Louisville |
| Experience: 3 |