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Ladd McConkey WR | LAC
Chargers' Ladd McConkey: No practice Wednesday
McConkey (foot) was a non-participant at Wednesday's practice.
McConkey attempted to play through a foot injury in Week 4, but when he exited this past Sunday's loss at Seattle in the third quarter, he had no catches among his two targets. Coach Jim Harbaugh told Alex Insdorf of BoltBeat.com on Monday that McConkey is "week-to-week," so his lack of activity to begin Week 5 prep lines up with that assessment. Friday's injury report ultimately may provide clarity on McConkey's status for Sunday's game against the Broncos.
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Pat Bryant WR | DEN
Broncos' Pat Bryant: Opens Week 5 prep with DNP
Bryant (ankle) did not participate in Wednesday's practice, Aric DiLalla of the Broncos' official site reports.
Bryant sprained his right ankle during the Broncos' Week 4 loss to the 49ers. An MRI did not reveal a high-ankle sprain, which is good news for the second-year wide receiver. Bryant is still expected to miss time, so he can be considered on the doubtful side for Sunday's AFC West showdown against the Chargers. He has a 9-133-1 receiving line (12 targets) through four games, and assuming Bryant is sidelined for Week 5, that workload will be absorbed by Jaylen Waddle, Courtland Sutton, Marvin Mims and Troy Franklin.
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Dante Pettis WR | SF
Dante Pettis: Placed on practice squad IL
The 49ers placed Pettis (undisclosed) on the practice squad injured list Wednesday.
The nature of Pettis' injury isn't clear, but it's severe enough for him to require a stint on the practice squad IL. As such, he is not eligible to be elevated to the active roster for at least the 49ers' next four games.
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Irvin Charles WR | SEA
Seahawks' Irvin Charles: Returns to practice
Charles (undisclosed) practiced Wednesday, John Boyle of the team's official site reports.
Charles is on injured reserve, though he's seemingly inching closer to getting back on the field. The 29-year-old, who was acquired from the Jets during the offseason, is expected to spend most of his time on special teams upon his return.
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Xavier Smith WR | LAR
Xavier Smith: Heads to Bay Area on practice squad
The 49ers signed Smith to the practice squad Wednesday.
Smith was cut by the Rams on Friday, but the Florida A&M product will stay in the NFC West division with the 49ers as a member of the practice squad. Smith would be a top candidate for an elevation to the active roster if the 49ers needed more depth at wide receiver.
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Justin Jefferson WR | MIN
Vikings' Justin Jefferson: Intends to play Sunday
Jefferson (ankle) said Wednesday that he's aiming to play Sunday at New Orleans, Kevin Seifert of ESPN reports.
Coach Kevin O'Connell provided an update on Jefferson earlier Wednesday, saying the wide receiver "is doing well" and will be limited to begin Week 5 prep. Jefferson's ensuing activity level indeed was limited, but per the player himself he wants to play against the Saints as a native of Louisiana. The Vikings will take the situation "day by day," and his listing on Friday's practice report may be telling for his odds to suit up this weekend.
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Jonathan Mingo WR | DAL
Cowboys' Jonathan Mingo: Under the weather, iffy for TNF
Mingo did not practice Wednesday due to an illness and is listed as questionable for Thursday's game against the Buccaneers, Tommy Yarrish of the Cowboys' official site reports.
Wednesday was the first time this week that Mingo popped up on the injury report, which casts uncertainty over his status for Thursday Night Football. He's seen just three targets through four regular-season games, but if Mingo isn't cleared to play, then undrafted rookie Camden Brown would be in line to be on the active gameday roster for the first time this season, with Ryan Flournoy and KaVontae Turpin both in the mix for a slight increase in offensive snaps.
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Mike Evans WR | SF
49ers' Mike Evans: Limited at Wednesday's practice
Evans (ribs) was listed as a limited participant for Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
With Evans managing the rib issue well enough to practice in a limited capacity after playing through it last Sunday, his status appears to be trending in the right direction ahead of the Niners' Week 5 date with the Seahawks. Evans has been dinged up seemingly all season already but has been productive through it all, catching 17 passes for 213 yards and two touchdowns on 24 targets.
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Savion Williams WR | GB
Packers' Savion Williams: Back at practice Wednesday
The Packers designated Williams (ankle) to return from injured reserve ahead of Wednesday's practice session.
Williams suffered a high-ankle sprain toward the tail end of training camp, which prompted the Packers to place the second-year wide receiver on injured reserve. He's progressed enough in his recovery to participate in practice, and the Packers have 21 days to activate Williams from IR. He'll likely need to log multiple full practices before being moved to the 53-man roster, but he could make his 2026 regular-season debut as soon as this Sunday's NFC North showdown against the Bears.
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Nick DeGennaro WR | NE
Nick DeGennaro: Added to Commanders' PS
The Commanders signed DeGennaro to the practice squad Wednesday, Jeremy Fowler of ESPN.com reports.
DeGennaro signed with the Patriots as an undrafted free agent, though he was cut in August. He will get another opportunity to make an NFL roster, and while that could happen in Washington, he likely wouldn't do anything to benefit fantasy managers.