Downs (concussion) didn't practice Wednesday.

With Downs in the NFL's concussion protocol, per Stephen Holder of ESPN.com, the wideout's status will need to be tracked ahead of this weekend's game against the Chargers. In this past Sunday's 31-27 win over the Cardinals, Downs logged a 51 percent snap share while catching six of his seven targets for 42 yards and a touchdown. If he's limited or out versus Los Angles, Ashton Dulin (chest) -- if available -- Adonai Mitchell and Anthony Gould would be candidates for added snaps alongside fellow WRs Michael Pittman and Alec Pierce.

San Francisco coach Kyle Shanahan said Pearsall (knee) will not practice Wednesday, Cam Inman of The San Jose Mercury News reports.

Shanahan said Monday that Pearsall would be evaluated Wednesday to determine his practice level for Week 7, so the 2024 first-round pick's lack of participation could be a sign that he isn't yet nearing a return to on-field reps. Meanwhile, QB Brock Purdy (toe), TE George Kittle (hamstring) and WR Jauan Jennings (ribs) all practiced in a limited capacity Wednesday, and all three appear to have a chance at playing Sunday versus the Falcons. Kittle remains on IR for the time being, however, while Jennings played through five broken ribs during San Francisco's loss to the Buccaneers in Week 6.

Samuel (heel) is listed as a non-participant on Wednesday's practice report.

He played through the same injury the past two games, putting up an 8-96-1 receiving line in Week 5 before slumping to 4-15-0 in Week 6. Samuel topped a 70 percent snap share in both games, but the Commanders might ease up on his workload some if the heel continues to give him trouble and WR Terry McLaurin (quad) is available to pick up slack. McLaurin is returning to practice this week, but it isn't yet clear if he'll be ready for Sunday's game at Dallas. Samuel also needs to be monitored, and there will be serious concern if he doesn't return to practice by Friday.

San Francisco head coach Kyle Shanahan said Jennings (ankle/rib/shoulder) will be limited in practice Wednesday, Cam Inman of The San Jose Mercury News reports.

Jennings played through five broken ribs, among other health concerns, during the 49ers' loss to Tampa Bay in Week 6, a contest in which he handled 77 percent of offensive snaps but secured just one of three targets for seven yards. While Jennings may again manage to play through his injuries at home against the Falcons on Sunday, he's combined for just three grabs for 31 yards (on seven targets) in his last two appearances. Meanwhile, Ricky Pearsall (knee) and Skyy Moore (undisclosed) are not practicing Wednesday.

McLaurin (quadriceps) is listed as a limited participant on Wednesday's practice report.

The report is just an estimate after the Commanders held a walk-through. McLaurin is expected to resume practicing in earnest Thursday, although presumably with limitations. Commanders coach Dan Quinn said Wednesday that he isn't sure if McLaurin will be ready for Sunday's game at Dallas.

Coker (quadriceps) was a full practice participant Wednesday, with Panthers coach Dave Canales saying afterward that the wideout looked great, Steve Reed of the Associated Press reports.

Coker was a full practice participant throughout last week but didn't get activated from injured reserve for Sunday's win over the Cowboys. He'll likely be ready this Sunday against the Jets, although Canales didn't commit to anything and said Coker will continue to be evaluated as the week progresses.

Slayton (hamstring) didn't practice Wednesday, Dan Salomone of the Giants' official site reports.

Slayton injured his hamstring during the Giants' Week 5 loss at New Orleans and hasn't practiced in the meantime, sitting out last Thursday's win against the Eagles in the process. He'll have two more chances this week to mix into drills before New York potentially makes a ruling on his status for Sunday's game at Denver.

Jaguars coach Liam Coen said Wednesday that he plans to design and call more plays with Hunter as the first read, ESPN's Michael DiRocco reports.

Hunter had career highs for snap share (79 percent) and route share (88 percent) in Sunday's loss to Seattle, but his seven targets largely came near the line of scrimmage (4.0 aDOT) and led to a meager 4-15-0 receiving line. He's already getting a few schemed touches each week yet has a much lower per-route target rate (19 percent) than teammates Brian Thomas (24 percent), Parker Washington (25 percent), Travis Etienne (23 percent) and Bhayshul Tuten (29 percent). The Jaguars could look to get Hunter more deep/intermediate targets, but that won't necessarily be easy to do against a tough Rams defense this Sunday in London.

Ridley (hamstring) wasn't spotted at practice Wednesday, Jim Wyatt of the Titans' official site and Turron Davenport of ESPN.com report.

Ridley was forced out of this past Sunday's 20-10 loss to the Raiders with a hamstring injury after logging just six snaps. The wideout now has two more opportunities to practice ahead of this weekend's game against the Patriots, but if Ridley ends up limited or sidelined, added snaps/targets would be available for Van Jefferson, who stepped into an expanded role in Week 6 following Ridley's departure.

Rams coach Sean McVay said Wednesday that Atwell (hamstring) will be limited at practice, Stu Jackson of the team's official site reports.

Atwell appears to be trending in the right direction to return from his one-game absence and play Sunday versus Jacksonville, as McVay already expressed optimism about the wideout's status during Monday's press conference. If Atwell can upgrade to full practice reps Thursday and/or Friday, he'll have a fair chance to avoid an injury designation entirely for Week 7.