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Justin Jefferson WR | MIN
Vikings' Justin Jefferson: Looking unlikely to play Monday
Jefferson (hamstring) is listed as questionable for Monday's game against the Bears but is considered unlikely to be activated from injured reserve ahead of the Week 12 contest, Adam Schefter of ESPN reports.
Since being designated for return from IR on Nov. 8, Jefferson has been listed as a limited participant in the Vikings' ensuing nine practices. Jefferson's lack of progression in terms of practice activity doesn't seem to be the result of any unexpected setbacks, as the wideout said this week that he's been able to run full speed during portions of those workouts. Additionally, head coach Kevin O'Connell said Saturday that Jefferson "took part in some team reps." Even so, the Vikings look like they'll continue to take a cautious approach with Jefferson and hold him out for a seventh game in a row, with confirmation on his status expected to come by 4 p.m. ET on Monday, the deadline for Minnesota and Chicago to make transactions leading up to the 8:15 p.m. ET kickoff. The Vikings are on bye Week 13, but the team is expected to formally activate Jefferson from IR before his 21-day evaluation window closes this coming Wednesday, setting the stage for him to return to the lineup for the team's Week 14 matchup with the Raiders on Dec. 10.
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Jalen Guyton WR | LV
Chargers' Jalen Guyton: Expected to suit up Sunday
Guyton (groin) is expected to suit up for Sunday's game against the Ravens, Adam Schefter of ESPN reports.
Guyton, who is officially listed as questionable, looks set to return to the field after having been sidelined Week 11 versus Green Bay. In his last appearance, Week 10 versus Detroit, Guyton secured four of six targets for 41 yards and a score, so it's possible he handles a significant role alongside top option Keenan Allen and rookie Quentin Johnston on Sunday. Guyton's status will be made official when the Chargers release their inactive list roughly 90 minutes prior to Sunday's 8:20 p.m. ET kickoff.
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Odell Beckham Jr. WR | MIN
Ravens' Odell Beckham: Expected to take on Chargers
Beckham (shoulder) is expected to suit up for Sunday's game against the Chargers, Adam Schefter of ESPN reports.
Beckham is officially listed as questionable for Sunday's game, but he practiced fully Friday and should be ready to take the field. His status will be made official when the Ravens release their inactive list 90 minutes ahead of Sunday's 8:20 p.m. ET kickoff, but having Beckham available would be a notable boon for a passing game already working without star tight end Mark Andrews (ankle).
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Zay Flowers WR | BAL
Ravens' Zay Flowers: Expected to play Sunday night
Flowers (hip) is expected to suit up for Sunday's game against the Chargers, Adam Schefter of ESPN reports.
Flowers practiced fully Friday but is officially listed as questionable heading into Sunday's game. The rookie first-round pick looks poised to suit up Sunday, though fantasy managers won't have official word on his status until the Ravens release their inactive list roughly 90 minutes ahead of the 8:20 p.m. ET kickoff. Fellow wideout Odell Beckham (shoulder) is also expected to suit up despite being listed as questionable.
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Marquise Brown WR | PHI
Cardinals' Marquise Brown: Expected to play Sunday
Brown (heel), who is listed as questionable for Sunday's game against the Rams, is expected to play, Adam Schefter of ESPN reports.
Brown looks on track to face Los Angeles, but his status may not be made official until the Cardinals release their inactive list roughly 90 minutes before Sunday's 4:05 p.m. ET kickoff. The return of quarterback Kyler Murray has resulted in a puzzling dip in Brown's production, with the wideout having posted just three catches for 46 yards without a touchdown over his last two appearances. Of course, Brown and Murray have a well-established rapport and should get back on track soon, and the two have a favorable Week 12 matchup. Brown's injury adds a complicating factor into the equation, though head coach Jonathan Gannon called the wideout's absences from practice this week "precautionary."
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David Sills WR | TB
Broncos' David Sills: Promoted to active roster
The Broncos elevated Sills from the practice squad Saturday.
This is the third time Sills has been elevated to the active roster, which means the Broncos will have to sign him to the 53-man roster after Sunday's game against the Browns if the team wants him to continue playing. Sills has played 11 snaps over his two appearances without recording a single stat.
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Quez Watkins WR | IND
Eagles' Quez Watkins: Activated off IR
The Eagles activated Watkins (hamstring) off injured reserve Saturday.
Watkins went on IR in mid-October after aggravating a hamstring injury Week 5 versus the Rams. The veteran receiver has played in just three games this season, catching four of five targets for 21 yards and returning one kickoff for 11 yards. Philadelphia signed Julio Jones during Watkins' absence, so if he plays Sunday against Buffalo, Watkins would likely slide in behind Jones, A.J. Brown and DeVonta Smith on the team's wide receiver depth chart.
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Steven Sims WR | ARI
Texans' Steven Sims: Promoted from practice squad
The Texans elevated Sims to the active roster Saturday.
This is the second time this season that Sims has been elevated. He was active in Week 11 against the Cardinals, when he caught both of his targets for 25 yards while returning two punts for 16 yards. Sims will provide wide receiver depth due to Noah Brown (knee) being ruled out for Sunday's divisional matchup against the Jaguars.
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Chris Blair WR | ATL
Falcons' Chris Blair: Promoted from practice squad
The Falcons elevated Blair to the active roster Saturday, Terrin Waack of the team's official site reports.
The move corresponds with Mack Hollins (ankle) being ruled out for Sunday's game against the Saints. Blair joined the Falcons' practice squad Sept. 27 after being cut from the team with an injury settlement Aug. 14.
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Andy Isabella WR | SF
Bills' Andy Isabella: Elevated for Sunday
The Bills elevated Isabella from their practice squad Saturday.
This is the second time Isabella has been elevated to the active roster this season since joining the Bills' practice squad Aug. 30. In his first appearance in Week 8 against the Buccaneers, Isabella played nine snaps on special teams without recording a stat.