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George Holani RB | SEA
Seahawks' George Holani: Totals 20 yards in Week 4 win
Holani rushed seven times for 18 yards in Sunday's 30-23 win over the Chargers. He added one catch for two yards on one target.
Even with Jadarian Price (chest) on injured reserve, Holani played a distant second fiddle to Emanuel Wilson, who rushed 21 times for 81 yards and a touchdown. Wilson also turned four targets into three catches for 30 yards and a second score. Holani has minimal fantasy value, especially with Zach Charbonnet (knee) due back in the near future.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Exits briefly but returns to Monday's game
Kamara temporarily exited Monday's game against the Falcons due to a knee issue but has since returned.
Kamara appeared to hurt his knee in the third quarter and headed to the medical tent. The veteran running back exited the tent, tested out his knee on the sideline, then briefly returned to the tent, but he was able to re-enter the contest before the end of the period. Kamara is serving as New Orleans' lead running back in the absence of Travis Etienne (ankle) and scored his first touchdown of the campaign earlier in Monday's contest.
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Kaelon Black RB | SF
49ers' Kaelon Black: Inefficient in Week 4 win
Black turned six carries into 13 yards during the 49ers' 24-14 win over the Broncos on Sunday.
Black's longest carry of the day went for five yards, with four of his other touches going for two yards or fewer. With Christian McCaffrey clearly leading the backfield, Black's workload will be volatile on a week-to-week basis and dependant on game script. The 49ers will hit the road for Week 5 in an NFC West showdown against the 3-1 Seahawks.
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Seth McGowan RB | IND
Colts' Seth McGowan: Seven touches in Week 4 victory
McGowan turned six carries into 31 yards and caught one of two targets for seven yards during Sunday's 30-13 win over the Commanders in London. He also returned four kickoffs for 102 yards.
McGowan actually saw most of his offensive output in the second quarter with four carries for 18 yards and his seven-yard catch. Most of his on-field production figures to come on special teams as a returner, but the rookie seventh-rounder would be thrust into RB1 duties if Jonathan Taylor were to miss time. The Colts will hit the road for Week 5 against the Steelers this Sunday.
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Austin Ekeler RB | WAS
Commanders' Austin Ekeler: Tallies 40 yards in 2026 debut
Ekeler turned four carries into 29 yards and added an 11-yard catch on two targets during the Commanders' 30-13 loss to the Colts on Sunday in London.
Ekeler signed with the Commanders on Tuesday and was immediately involved in the offense Sunday due to the absence of Rachaad White (shoulder). Ekeler's 17 offensive snaps were second-most on the Commanders behind Jacory Croskey-Merritt (29) and ahead of rookie Kaytron Allen (12). However, despite logging only four carries, Ekeler's 29 rushing yards were most among Washington's running backs and second on the team behind QB Marcus Mariota (35). Given Ekeler's efficiency in limited touches, he could remain involved in the gameplan for Week 5 against the Giants even if White is cleared to return.
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Justice Hill RB | BAL
Ravens' Justice Hill: Three touches in Week 4 win
Hill rushed one time for three yards in Sunday's 24-18 win over the Titans. He added two catches for 22 yards on three targets.
Hill continues to handle change-of-pace and passing-down work behind Derrick Henry out of the Baltimore backfield. Across four games, Hill has accumulated 60 rushing yards on 14 carries and five catches for 44 yards on six targets. Hill's role would likely only expand in the event the Ravens are chasing points on the scoreboard or if Henry suffers an injury.
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Najee Harris RB | NYG
Giants' Najee Harris: Loses fumble in win
Harris logged nine carries for 30 yards and lost a fumble in the Giants' 36-24 win over the Cardinals on Sunday.
Harris saw half the carries of Cam Skattebo as the Giants' primary relief option in Sunday's contest. The running back coughed up the football to Mack Wilson on the Cardinals' 42-yard line in the fourth quarter when the score was 27-24 Giants. The Giants' defense held strong to close out the contest despite Harris' mistake.
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Kaleb Johnson RB | GB
Packers' Kaleb Johnson: Fumbles during crucial play in win
Johnson logged eight carries for 42 yards and lost one fumble in the Packers' 17-14 win over the Buccaneers on Sunday.
Johnson had a strong 5.3 yards per carry in the win but coughed up the football in a close game. The running back relinquished the ball to Tykee Smith with 9:13 remaining in the fourth quarter on the Tampa Bay 4-yard line while the Packers were up by only three points. The defense held off the Buccaneers' offense, but it appears the Packers chose to ride MarShawn Lloyd to finish out the game.
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Craig Reynolds RB | WAS
Craig Reynolds: Reverting to practice squad
Reynolds reverted to the Commanders' practice squad Monday, per the NFL's transaction log.
Reynolds took two carries for four yards during Washington's 30-12 loss against the Colts in Week 4. Whether he's brought up again in Week 5 may depend on the availability of Rachaad White (shoulder).
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Sean Tucker RB | TB
Buccaneers' Sean Tucker: Punches in short touchdown
Tucker rushed three times for 10 yards and a touchdown in Sunday's 17-14 loss to the Packers.
Tucker played three offensive snaps and handled a carry on all of them, punching in a short two-yard touchdown in the second quarter. Tucker would likely be the biggest beneficiary in the event of a Bucky Irving injury, leaving Kenny Gainwell in a change-of-pace receiving role.