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Darrel Williams RB | NO
Chiefs' Darrel Williams: Inactive for Sunday's game
Williams (coach's decision) is inactive for Sunday's game at Pittsburgh, Adam Teicher of ESPN.com reports.
The specifics surrounding Williams' inactive status have yet to be released, but it's unlikely the LSU product would have had any major impact during Sunday's contest anyway. Slotted as the team's No. 4 running back, Williams will need to carve out a larger special teams role if he plans on keeping a roster spot for the entire 2018 season.
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Roc Thomas RB | JAC
Vikings' Roc Thomas: Won't suit up Sunday
Thomas (coach's decision) is listed as inactive for Sunday's game against the Packers.
Thomas was sidelined during Week 1 due to an ankle injury, but returned to full participation at practice Wednesday. He'll be a healthy scratch Sunday, however, while Dalvin Cook and Latavius Murray handle the work out of the backfield.
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Ronald Jones RB | DAL
Buccaneers' Ronald Jones II: Remains inactive Week 2
Jones (coach's decision) is inactive for Sunday's Week 2 tilt against the Eagles, Scott Smith of the Buccaneers' official site reports.
Jones will thus spend the first two games of his professional career on the sidelines, a result of both Peyton Barber's clear hold on the No. 1 running back role and Jones' own deficiencies in the preseason. The rookie's next chance to make his NFL debut comes in a Week 3 Monday night matchup against the Steelers.
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Christine Michael RB | IND
Colts' Christine Michael: Inactive against Washington
Michael is inactive for Sunday's game at Washington.
With Marlon Mack returning after missing Week 1 with a hamstring injury, Michael may be stuck on the bench most of the season. Jordan Wilkins and Nyheim Hines will figure into the RB mix along with Mack, leaving little room for Michael.
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Mike Boone RB | MIA
Vikings' Mike Boone: Inactive Sunday
Boone (coach's decision) is listed as inactive for Sunday's game against the Packers.
Boone is listed as a healthy scratch for the second consecutive week alongside fellow reserve Roc Thomas, leaving Dalvin Cook and Latavius Murray as the only running backs in uniform Sunday.
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Marlon Mack RB | ARI
Colts' Marlon Mack: Will suit up Week 2
Mack (hamstring) is active Sunday against the Redskins.
Reports earlier Sunday suggested Mack would be ready to make his season debut Week 2, but the team wanted to get a good look at the back during pregame warmups before making it official. While Mack will suit up and be part of the backfield mix, it wouldn't be out of the question for rookies Jordan Wilkins and Nyheim Hines to still have a role. The Colts will be squaring off against a Washington defense that gave up just 68 yards on the ground in Week 1 and limited star running back David Johnson to 37 yards rushing.
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Marlon Mack RB | ARI
Colts' Marlon Mack: Trending toward active status
The Colts are optimistic that Mack (hamstring), who is listed as questionable for Sunday's game against the Redskins, will suit up in Week 2, Ian Rapoport of NFL Network reports.
Indianapolis will observe Mack in pregame warmups just to be certain that he's good to go, but the tailback seemingly proved his health by putting in a pair of limited practices and one full session earlier in the week. Even if Mack gains clearance to play, it's not guaranteed that he'll head the Colts' backfield committee right away, which could make him an unappealing lineup choice in most shallower settings. Rookie backs Jordan Wilkins and Nyheim Hines are still both likely to have roles in head coach Frank Reich's game plan.
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Brandon Wilds RB | JAC
Jaguars' Brandon Wilds: Promoted from practice squad
Wilds was promoted to the active roster on Saturday, Ian Rapoport of NFL Network reports.
Wilds was released in final cuts earlier this month. His promotion to the active roster seems to indicate the team may have concern about starting running back Leonard Fournette's (hamstring) health entering Sunday's game against the Patriots. Look for Wilds to serve as the No. 3 option at halfback if Fournette is sidelined.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Undergoes successful surgery
Mixon (knee) underwent successful arthroscopic surgery Saturday and is expected to be sidelined for 2-4 weeks, Ian Rapoport of NFL Network reports.
The extra time between games will benefit Mixon's recovery timeframe, but he is still likely to miss at least one game. The second-year running back was clearly playing through pain in the second half of Thursday's 34-23 victory over the Ravens, so he and the Bengals opted for the surgery route in order to get ahead of the curve and avoid a lingering issue. Giovani Bernard figures to be primed for a large workload in the immediate future while MIxon is sidelined.