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Miles Sanders RB | DAL
Eagles' Miles Sanders: Suffers knee injury
Sanders (knee) is questionable to return to Sunday's game against the Ravens, Dave Zangaro of NBC Sports Philadelphia reports.
Sanders' last touch came midway through the third quarter when he scampered 74 yards and fumbled just before the goal line. Fortunately for the Eagles, J.J. Arcega-Whiteside made the recovery in the end zone for the team's first points of the day, but Sanders may have been lost for the game in the process. Since then, Boston Scott has been the only Philly RB to handle touches out of the backfield.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Injures right foot
Mixon exited Sunday's game against the Colts after sustaining a right foot injury.
Prior to his exit from the contest, Mixon had carried 11 times for 44 yards and a TD. Next up for the team's carries are Giovani Bernard and Samaje Perine.
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Jordan Wilkins RB | CLE
Colts' Jordan Wilkins: Will play vs. CIN
Wilkins (calf) is active Week 6 against Cincinnati.
Wilkins was trending in the wrong direction after missing practices Thursday and Friday, but he'll ultimately end up suiting up for the home matchup. Even though Wilkins will play, expect him to concede most early-down work to Jonathan Taylor, with Nyheim Hines in line to see his regular responsibilities on passing downs.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Likely to return Week 8
Per Tom Pelissero on NFL Network, Cook (groin) has a "99.999 percent chance" to return for the Vikings' Week 8 game at Green Bay on Sunday, Nov. 1.
Cook was knocked from Minnesota's Week 5 loss at Seattle with what was eventually termed an adductor strain, an injury that will sideline him Sunday against the Falcons. With the benefit of a Week 7 bye, there's hope Cook will be past the issue in time for a divisional showdown with the Packers. On the season, he's averaging 20.8 touches per game, most of which are expected to filter down to Alexander Mattison in the short term. Mike Boone, C.J. Ham and Ameer Abdullah also are candidates to see work out of the backfield during Cook's absence.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Recovering from strep throat
Gordon (illness), who was ruled out for Sunday's game against the Patriots, is recovering from a bout with strep throat, Tom Pelissero of NFL Network reports.
Gordon didn't travel with the Broncos to New England on Saturday, ending a turbulent week for the running back, who was cited late Tuesday on DUI and speeding charges. The Broncos chose to hold him out of Wednesday's practice, but Gordon was back at work Thursday before being sent home Friday after feeling sick. Gordon was determined to be dealing with a non-COVID-19-related illness, but he'll still need a few days to recover before likely rejoining the Broncos for practice Week 7. Regarding the off-field incident, the Broncos have chosen not to fine or suspend Gordon, but the 27-year-old could be subject to punishment from the league at a later date. Recent precedent for similar cases typically entails a three-game suspension, but the NFL may elect to wait and see how Gordon's legal process plays out before levying any ban. Gordon's arraignment is scheduled for Nov. 13.
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Zack Moss RB | CIN
Bills' Zack Moss: Ready for action
Moss (toe) practiced fully for the third straight day Saturday and does not have an injury designation heading into Monday's game against Kansas City.
Moss hasn't played since suffering the injury Week 2, and given his increased practice work to go with the fact the Bills had trouble running the ball up the middle Tuesday against Tennessee, we'd be pretty surprised if he isn't on Monday's active roster. That said, Devin Singletary is still the starter and T.J. Yeldon looked good as a change-of-pace back Tuesday, so Moss may be on a limited play count as he continues to get up to speed in his rookie season.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Out ahead of Sunday
Gordon (illness) will not travel with the team to New England and has been ruled out ahead of Sunday's game, Mike Klis of 9News Denver reports.
The move seems to be billed as a precautionary measure although all indications suggest Gordon is not suffering from a COVID-related illness. It's unclear whether the 27-year-old's legal matters are also factoring into the decision, but in any case Phillip Lindsay, who just returned from a multi-week absence from a toe injury, will be the primary option for most of the running back reps, with Royce Freeman occasionally chipping in as a pass catcher out of the backfield.
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Alexander Mattison RB | MIA
Vikings' Alexander Mattison: In line for lead role
Mattison will be the Vikings' No. 1 running back Sunday against the Falcons with Dalvin Cook (groin) sidelined for the contest, Chris Tomasson of the St. Paul Pioneer Press reports.
The Vikings made the expected move and formally ruled out Cook, who suffered an adductor strain Week 5 in Seattle. Prior to his departure in the third quarter, he had 22 touches, and he also averaged 20.5 touches through the first four games of the campaign. By the end of this past Sunday's 27-26 loss, Mattison himself racked up 23 touches for 136 yards from scrimmage, so he seems poised to handle a significant workload this weekend. As a result, he seems like a great bet to produce versus an Atlanta defense that has given up 139 total yards per game to running backs in 2020. Mattison's opportunity may be short-lived with a Week 7 bye on tap.