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James Robinson RB | NO
Jaguars' James Robinson: Practices in limited fashion
Robinson (heel/knee) was a limited participant at Wednesday's practice.
Robinson continues to deal with the two injuries, but the fact he was able to practice Wednesday in some fashion indicates he didn't aggravate anything during Sunday's loss to the Falcons. The 23-year-old has avoided an injury designation the past few games despite starting each week with limitations, and he may be on a similar track Week 13.
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Boston Scott RB | PIT
Eagles' Boston Scott: Misses practice with illness
Scott didn't practice Wednesday due to an illness.
He'll likely have time to get healthy before Sunday's game against the Jets, but Scott's absence to begin Week 13 prep adds another layer of intrigue to the Eagles' backfield situation heading into that contest. Scott dominated the backfield touches after Miles Sanders' (ankle) early exit from last week's 13-7 loss to the Giants, but Scott lost a crucial fumble late in the game, and Sanders then managed to practice Wednesday (albeit on a limited basis). Meanwhile, Jordan Howard (knee) missed another practice and seems least likely of the trio to play, leaving rookie Kenneth Gainwell as the only healthy back on the roster as of Wednesday. There's a scenario where Scott handles the lead role this week, if he recovers from the illness and if Sanders fails to overcome the ankle injury. The Eagles' injury reports Thursday and Friday should help sort out the mess.
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Dalvin Cook RB | DAL
Vikings' Dalvin Cook: Listed as non-participant Wednesday
Cook (shoulder) was listed as a non-participant on Wednesday's estimated injury report.
Considering he's tending to a dislocated left shoulder, Cook wouldn't have been on the field if the Vikings held an actual practice. There's an expectation that the injury will force him to miss the next two games, according to Adam Schefter of ESPN, but head coach Mike Zimmer offered a softer tone Monday, calling the running back day-to-day, per Eric Smith of the Vikings' official site. Despite Zimmer's lack of commitment on Cook's status, the running back appears as if he'll be ruled out for game action by week's end. Assuming Cook doesn't play Sunday in Detroit, Alexander Mattison will be the primary runner out of Minnesota's backfield, with rookie Kene Nwangwu available for complementary work.
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Miles Sanders RB | DAL
Eagles' Miles Sanders: Practices on limited basis
Sanders (ankle) was a limited practice participant Wednesday, while backfield mates Boston Scott (illness) and Jordan Howard (knee) sat out the session.
Things have quickly turned in Sanders' favor since he sat out the fourth quarter of Sunday's 13-7 loss to the Giants with an ankle injury, though he's still likely to share snaps and carries if he ends up playing this week, given that Scott is reportedly dealing with a non-COVID-19 illness and rookie Kenneth Gainwell remains healthy. The Eagles face the Jets on Sunday, providing a favorable matchup for whichever running backs end up playing and getting touches.
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Alvin Kamara RB | NO
Saints' Alvin Kamara: Questionable for Week 13
Kamara (knee) is listed as questionable for Thursday's game against the Cowboys.
Kamara maintained limited listings on all three of the Saints' Week 13 injury reports as he attempts to make his way back from an MCL sprain that has forced him to miss the past three contests. At the same time, Mark Ingram (knee) was a full participant Monday through Wednesday and is ready to handle as many backfield reps as needed if Kamara has to sit out a fourth consecutive game. The Saints will reveal Kamara's availability about 90 minutes before Thursday's 8:20 p.m. ET kickoff.
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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Not on injury report
Barkley isn't listed on the Giants' Week 13 injury report, Adam Caplan of SiriusXM NFL Radio reports.
While his production has been lackluster in his first two contests back from a five-week stint on injured reserve, Barkley has quickly reclaimed his usual three-down role out of the backfield, playing 62 percent of the GIants' offensive snaps Week 11 and then 87 percent Week 12. He's set for a full workload Sunday in Miami, serving as the centerpiece of a struggling, injury-riddled offense that may have Mike Glennon filling in at quarterback for the injured Daniel Jones (neck).
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Chase Edmonds RB | WAS
Cardinals' Chase Edmonds: Expected back Week 14
Head coach Kliff Kingsbury anticipates Edmonds (ankle) returning for a Week 14 matchup with the Rams on Dec. 13, Bob McManaman of the Arizona Republic reports.
At that point, Edmonds will be five weeks removed from the initial injury, a high-ankle sprain he suffered on the first snap of a Week 9 loss to the 49ers. He then missed the Cardinals' following two games before their Week 12 bye, and he'll be out again Week 13 in Chicago, giving James Conner at least one more game in a dominant role. After that, it'll likely be back to a timeshare out of the backfield once Edmonds is deemed healthy.
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Melvin Gordon RB | BAL
Broncos' Melvin Gordon: Not practicing Wednesday
Gordon won't practice Wednesday due to hip and shoulder injuries, George Stoia III of The Denver Gazette reports.
While Gordon is evidently banged up following the Broncos' Week 12 win over the Chargers, head coach Vic Fangio suggested that the running back will have a chance to make it back to practice Thursday, per Aric DiLalla of the Broncos' official site. If that happens, Gordon would presumably be on track to suit up Sunday against Kansas City and work in tandem with fellow running back Javonte Williams.
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D'Andre Swift RB | CHI
Lions' D'Andre Swift: Could sit out multiple games
Swift (shoulder) didn't practice Wednesday and could miss multiple games, though he wants to return in short order, Jeremy Fowler of ESPN.com reports.
Swift is reportedly dealing with an AC joint sprain, an injury that could prompt the winless Lions to take a cautious approach with one of their few core players until his shoulder heals. Though Swift hasn't been ruled out from playing in Sunday's game against the Vikings, he seems more likely than not to miss his first contest of the season. If that's the case, Jamaal Williams would be in store for a lead role Sunday, with rookie Jermar Jefferson and 27-year-old journeyman Godwin Igwebuike representing the depth options currently on the active roster.
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Antonio Gibson RB | NE
Football Team's Antonio Gibson: Limited in practice, per usual
Gibson (shin) was a limited practice participant Wednesday, John Keim of ESPN.com reports.
Gibson continues to log limited practices while playing through a stress fracture of his shin, but it hasn't prevented him from taking on a sizable workload of late. Over each of the past three games, Gibson has handled 19 or more carries, including a 36-touch effort with 146 total yards in Mondays 17-15 win over Seattle. Matching that sort of volume is a tall task, but Gibson could take on another larger-than-usual snap share Sunday in Las Vegas, as passing-down back J.D. McKissic missed Wednesday's practice after suffering a concussion Monday.