Vaki (groin) has been ruled out for Sunday's game against the Chiefs, Justin Rogers of DetroitFootball.net reports.

Vaki has not been able to practice since suffering a groin injury in Week 3 against the Ravens. He'll miss a third consecutive game due to the injury, and the 2024 fourth-rounder's next opportunity to play is Week 7 against Tampa Bay on Monday, Oct. 20. Craig Reynolds and Jacob Saylors will continue to serve as the Lions' depth backfield options behind Jahmyr Gibbs and David Montgomery.

Tuten (shoulder) doesn't have a designation for Sunday's contest versus the Seahawks.

Tuten was listed as limited on Wednesday's practice estimate due to a lingering shoulder injury and then had a cap on his reps both Thursday and Friday. However, it won't stop him from continuing to serve as the Jaguars' No. 2 RB behind starter Travis Etienne. Such a role has amounted to 26 touches for 128 yards from scrimmage and two total TDs for Tuten over the last four games.

Executive Vice President Stephen Jones said Friday that Sanders will undergo season-ending knee surgery, Todd Archer of ESPN.com reports.

Sanders initially was forced out Week 4 against the Packers due to an ankle injury and then didn't suit up this past Sunday at the Jets due to listed knee and ankle issues. It appears the knee is the greater concern for Sanders following Jones' announcement, and the running back will finish the 2025 campaign with 20 carries for 117 yards and one touchdown and eight catches (on eight targets) for 30 yards in parts of four games. Jaydon Blue will step into the No. 2 role behind starting RB Javonte Williams moving forward.

Gibson (knee) was placed on injured reserve Friday.

This move was expected after Gibson was diagnosed with a torn ACL following New England's Week 5 win over the Bills. He'll finish the campaign with 25 carries for 106 yards and one touchdown, as well as two catches for six yards on three targets. Terrell Jennings likely will be elevated from the practice squad to provide depth behind Rhamondre Stevenson and TreVeyon Henderson against the Saints on Sunday, while Jashaun Corbin is another backfield option on the practice squad.

Rodriguez (calf) is listed as a non-participant on Friday's practice estimate.

Rodriguez didn't practice Thursday and apparently wouldn't have partaken Friday if the Commanders had held a practice. A return Saturday could still give him a chance to play Monday against the Bears, though all signs point to Jacory Croskey-Merritt leading Washington's backfield this week.

Blue will serve as the Cowboys' No. 2 RB behind starter Javonte Williams moving forward after Miles Sanders (knee/ankle) was ruled out for the rest of the season, Jon Machota of The Athletic reports.

Sanders initially hurt his ankle just before halftime of Dallas' Week 4 tie with the Packers and then was listed with knee and ankle injuries ahead of being inactive this past Sunday at the Jets. A limited practice this Wednesday indicates Sanders was making a last-ditch effort to prove his health, but Executive Vice President Stephen Jones said Friday that he'll miss the remainder of the campaign. Blue made his pro debut Week 5 and turned four carries into seven yards on 11 offensive snaps, so he likely will be contained to scraps behind the workhorse that has been Williams for the foreseeable future.

Sanders (knee/ankle) will miss the rest of the season, Jon Machota of The Athletic reports.

Cowboys EVP Stephen Jones said the team is "fired up" about what Jaydon Blue can do as the No. 2 running back. The rookie had just seven yards on four touches in the first game Sanders missed, with Javonte Williams again dominating backfield work. In any case, Sanders apparently will be placed on injured reserve soon.

Spears (ankle) doesn't have an injury designation for Sunday's game against the Raiders, Jim Wyatt of the Titans' official site reports.

Spears upgraded to full participation in Friday's practice after a pair of limited sessions. After handling just four carries for 14 yards in his Week 5 season debut against the Cardinals, Spears will look to take on a larger role Sunday as the complementary option to Tony Pollard in Tennessee's backfield.

Singletary rushed three times for 10 yards and didn't log any receiving targets in Thursday's 34-17 win against Philadelphia.

Singletary continued to get a bit of work even with the return of Tyrone Tracy to New York's backfield, but neither Singletary nor Tracy did anything of note. Meanwhile, rookie Cam Skattebo continued to cement his status as the team's workhorse back with 19 carries for 98 yards and three touchdowns along with two catches for 12 yards. Skattebo was on the field for 71 percent of the Giants' offensive plays, followed by Tracy at 30 percent and Singletary at a modest six percent (four total snaps). Given that usage, it appears Singletary will fade back into the No. 3 RB role when both Skattebo and Tracy are healthy, giving the veteran very little fantasy value.

Monangai (thigh) was a full practice participant Friday.

The rookie came out of a Week 5 bye listed with a new injury, but he'll apparently be fine for Monday's game at Washington, likely filling his usual role as the No. 2 running back. Monangai took 20 touches for 85 yards over the first four weeks of the season, failing to make a move despite D'Andre Swift's mediocre results as the lead back.