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Kirk Cousins QB | LV
Raiders' Kirk Cousins: Gives way to Mendoza late in rout
Cousins completed 19 of 28 passes for 243 yards and a touchdown in Sunday's 45-17 loss to the Patriots.
The lopsided result owed much more to the fact that the Raiders defense couldn't stop Drake Maye than it did to Cousins' performance, but it still provided coach Klint Kubiak with an opportunity to give Fernando Mendoza his first snaps in the NFL on the team's final drive. Las Vegas has lost two straight games with Cousins under center after a 3-0 start, and while the veteran QB has a more than respectable 12:4 TD:INT and 65.1 percent completion rate in his five starts, he was always going to be a placeholder until the first overall pick in the 2026 draft was deemed ready to take over. A switch at quarterback may not be imminent, but the clock is ticking on Cousins' tenure as the starter heading into a Week 6 battle with the Bills.
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Bo Nix QB | DEN
Broncos' Bo Nix: Switch in play callers falls flat
Nix was 16-for-27 passing for 123 yards, one touchdown and no interceptions, took four carries for 10 yards and fumbled twice (one lost) during Sunday's 23-17 victory at the Chargers.
With head coach Sean Payton taking over play-calling duties from offensive coordinator Davis Webb in Week 5, the decision didn't exactly light a fire under Nix and the Broncos offense. Nix settled for his fewest passing yards of the season, but he at least tossed a TD pass (to WR Courtland Sutton) for a fifth game in a row to kick off the campaign, giving him a 6:3 TD:INT so far. Nix may have a tough time producing better results on a short week when Denver hosts the defending champion Seahawks on Thursday night.
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Will Campbell OT | NE
Patriots' Will Campbell: Likely dealing with sprained knee
Campbell is believed to have suffered a sprained knee during Sunday's 45-17 win over Las Vegas, Ian Rapoport of NFL Network reports.
Campbell sustained the injury in the first half, and he will undergo an MRI on Monday to confirm the diagnosis. The 22-year-old will likely miss action moving forward, and in his absence, Caleb Lomu is a top candidate to fill in as the team's starting left tackle.
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Ashton Jeanty RB | LV
Raiders' Ashton Jeanty: Held in check in loss to Pats
Jeanty carried the ball 10 times for 27 yards and caught three of six targets for 50 yards in Sunday's 45-17 loss to New England.
A 31-yard catch in the fourth quarter salvaged Jeanty's day to some extent, but he wasn't able to cash in the red-zone opportunity he created as Dylan Laube instead ran in a two-yard score. Jeanty's rushing yards total was a season low, and he's still looking for his first rushing TD while averaging just 3.3 yards per carry, keeping his fantasy value afloat with a 22-215-2 line on 30 targets through five games. He'll look for more success on the ground in Week 6 against what has been a vulnerable Bills run defense.
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Jameson Williams WR | DET
Lions' Jameson Williams: Breaks season-long TD drought
Williams brought in two of four targets for 47 yards and two touchdowns in the Lions' 45-21 win over the Cardinals on Sunday.
Williams made good use of both his receptions by recording his first two touchdowns of the campaign, which came from eight and 39 yards out. The speedy 2022 first-round pick had already managed another first in Week 4 against the Panthers when he eclipsed the century mark, and Williams now has reached another milestone in what has been a reasonably productive start to the season. Williams is now averaging a robust 15.3 yards per reception heading into the Lions' Week 6 bye, and he should continue to play an important downfield role in a divisional showdown with the Packers at Ford Field on Sunday, Oct. 25.
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Teagan Quitoriano TE | ARI
Cardinals' Teagan Quitoriano: Scores pair of touchdowns in blowout loss
Quitoriano caught both of his targets for 15 yards and two touchdowns during Sunday's 45-21 loss to Detroit.
Quitoriano entered Sunday having recorded just two receptions since the beginning of the 2023 campaign. The tight end made the most of his two chances in Week 5, reeling in a two-yard touchdown pass from Jacoby Brissett in the first quarter before later connecting with the quarterback again for a 13-yard score in the third quarter. Quitoriano's performance figures to be an anomaly, and he carries no fantasy value moving forward.
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Zach Charbonnet RB | SEA
Seahawks' Zach Charbonnet: Will sit again Week 6
Charbonnet (knee) won't be activated from the reserve/PUP list ahead of Thursday's game versus the Broncos, Seahawks coach Mike Macdonald said after Sunday's 32-29 loss to the 49ers, Corbin Smith of Emerald City Spectrum reports.
Charbonnet returned to practice leading up to Sunday's loss against the 49ers, opening up a 21-day window for the Seahawks to add him back to the active roster. Seattle dropped to 3-2 with the loss, but the Seahawks are content to continue taking a patient approach with Charbonnet's recovery from a torn ACL rather than trying to rush him back on a short week. Charbonnet's next chance to suit up will come Oct. 25 against the Chiefs, while Emanuel Wilson, George Holani and Velus Jones will continue to hold the fort at running back against the Broncos in the absence of Charbonnet and Jadarian Price (chest), who is on IR until at least Week 8.
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Brock Bowers TE | LV
Raiders' Brock Bowers: Stays productive in tough Week 5 loss
Bowers caught eight of 10 targets for 110 yards and a touchdown in Sunday's 45-17 loss to the Patriots.
He did lose a fumble, but otherwise Bowers was the only Raider to put together a strong performance in the rout, catching a 13-yard TD from Kirk Cousins in the first quarter to tie the game at 7-7 before things got out of hand. The superstar tight end has gotten into the end zone in all three of his games this season and topped 100 yards twice, compiling a 24-312-3 line on 35 targets. Fernando Mendoza saw his first NFL action on Las Vegas' final drive after the team had pulled its starters, including Bowers, so the duo didn't get a chance to start building any chemistry. Bowers will look to keep rolling in a Week 6 clash with the Bills.
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Justin Herbert QB | LAC
Chargers' Justin Herbert: Two more turnovers in Week 5
Herbert completed 14 of 24 passes for 121 yards, one touchdown and one interception, reeled off 54 yards on six carries and fumbled twice (one lost) during Sunday's 23-17 loss to the Broncos.
Herbert's season-low number of pass attempts amounted to by far his lowest yardage total through the air through five contests this season. He also turned over the ball two times, which resulted in two late made field goals for Denver (i.e. the margin of defeat) and bringing his total on the campaign to nine (seven INTs, two lost fumbles). Granted, Herbert was working without WR Quentin Johnston (chest, inactive), while Ladd McConkey (foot) was active but doesn't appear to have played a snap, so the deck was stacked against him versus a tough defense. Herbert's next chance to get right is next Sunday versus the 4-0 Chiefs.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Reaches end zone in victory
Perine rushed 14 times for 68 yards while catching both of his targets for 10 yards and a touchdown during Sunday's 31-24 win over Miami.
Perine surprisingly logged one more carry than starting running back Chase Brown (13) in the contest. Additionally, although he saw two fewer targets than Brown, Perine was able to reach paydirt in the second quarter, reeling in a six-yard touchdown pass from Joe Burrow. Perine remains a highly valuable handcuff option for fantasy managers with Chase Brown on their rosters. Through five games, the 31-year-old has rushed 27 times for 110 yards while reeling in seven of 10 targets for 61 yards and a score.