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Derrick Henry RB | BAL
Titans' Derrick Henry: Quiet night besides early TD
Henry rushed 13 times for 25 yards and a touchdown in Monday's 41-7 loss to the Bills.
Henry rumbled in for a two-yard touchdown on fourth down to cap Tennessee's first drive but was bottled up for the rest of the night as the Titans were outplayed in every facet of the game. Through two games, Henry has averaged just 3.1 yards per carry, as opponents are stacking the box and Tennessee's passing game is failing to make them pay. Henry should find more running room in Week 3 against the Raiders, but the Titans' inability to replace A.J. Brown's production through the air has clearly bled into Henry's production on the ground.
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Avery Williams RB | NYJ
Falcons' Avery Williams: Catches one pass in Week 2
Williams had zero carries but hauled in his only target for six yards during Sunday's 31-27 loss to the Rams.
Williams finished second among running backs with 23 offensive snaps during the season opener, but he saw a reduced workload with rookie fifth-round pick Tyler Allgeier active for his first career NFL game. Williams played 15 offensive snaps and recorded just one touch. With Damien Williams (ribs) on IR, it appears like Allgeier will be the primary backup to Cordarrelle Patterson, while Avery continues to operate in a limited role.
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Jordan Mason RB | MIN
49ers' Jordan Mason: Injury opens up No. 2 job
Mason will take over the No. 2 spot on the 49ers' running back depth chart following the news that Tyrion Davis-Price (ankle) will miss several weeks, Jennifer Lee Chan of NBC Sports Bay Area reports.
Davis-Price -- who appeared to beat the undrafted Mason for the No. 2 job in practice last week -- suffered the injury late in Sunday's 27-7 win over Seattle. Mason served as the third active back and did not receive a touch (eight snaps on special teams), so it's hard to get excited about the undrafted rookie's new elevated role. Chan also added that practice squad veteran Marlon Mack is a candidate to be elevated to the active roster, so he could leapfrog the less-experienced Mason. However the backup spots shake out, Jeff Wilson (20 touches for 103 yards) was the clear lead back in Sunday's win, making him the desired fantasy target for running back stats in San Francisco heading into a matchup against the Broncos on Sunday Night Football.
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Craig Reynolds RB | WAS
Lions' Craig Reynolds: Four touches against former team
Reynolds rushed three times for 16 yards while securing his only target for 13 yards during Sunday's 36-27 win over Washington.
After being contained to special teams in the season opener, Reynolds saw some modest run, possibly because of D'Andre Swift's reported ankle sprain. He was efficient in doing so, but he didn't see nearly enough playing time behind Swift and Jamaal Williams to have a chance at fantasy relevance.
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Jamaal Williams RB | NO
Lions' Jamaal Williams: Given majority of carries
Williams rushed 12 times for 53 yards while catching his only target for seven receiving yards during Sunday's 36-27 win over Washington.
Williams handled the bulk of the rushing workload while D'Andre Swift bounced back from an ankle sprain. However, Swift still outproduced Williams by gaining 56 yards on his five carries, perfectly exemplifying the explosiveness Swift brings relative to Williams. While Williams nonetheless will be leaned on frequently to take pressure off Swift, he'll likely need to find the end zone to have worthwhile fantasy utility in any given week.
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Ty Chandler RB | NO
Vikings' Ty Chandler: Inactive Monday
Chandler (coach's decision) is inactive Monday against the Eagles.
Chandler will have to wait another week to try and make his NFL debut, as he remains behind Dalvin Cook, Alexander Mattison and Kene Nwangwu on the depth chart. The rookie will keep working to push his way up the Vikings' ranks and earn a chance to suit up in Week 3 against the Lions.
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Trey Sermon RB | ATL
Eagles' Trey Sermon: Sitting again Week 2
Sermon (coach's decision) is inactive for Monday's game against the Vikings.
Since joining the Eagles after roster cutdowns Sept. 1, Sermon has been a healthy scratch for both of the team's contests. This may be his reality without an injury to a member of the backfield, which is paced by Miles Sanders with Kenneth Gainwell and Boston Scott in reserve.
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Tyrion Davis-Price RB | GB
49ers' Tyrion Davis-Price: Set to miss time with ankle injury
Coach Kyle Shanahan relayed Monday that Davis-Price will miss a few weeks with a high-ankle sprain, Jennifer Lee Chan of NBC Sports Bay Area reports.
With Elijah Mitchell (knee) on IR, Davis-Price stepped into an increased role in the 49ers backfield Week 2 behind Jeff Wilson, carrying the ball 14 times for 33 yards. Now that Davis-Price is in line to miss some time, rookie Jordan Mason, who joined the team as an undrafted free agent in May, now should have an opportunity to carve out a complementary role in the coming weeks, while Marlon Mack is a candidate to be promoted from the team's practice squad.
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Patrick Taylor RB | SF
Patrick Taylor: Goes back to practice squad
Taylor reverted to the Packers' practice squad Monday, per the NFL's official transaction report.
Taylor got the call to be the Packers' No. 3 running back Sunday against the Bears with Kylin Hill (knee) still on the PUP list. However, he never saw the field on offense and only contributed on eight special-teams snaps. With Hill out for at least two more weeks, Taylor will look to earn another chance with the active roster Sunday against the Buccaneers.
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Matt Breida RB | SF
Giants' Matt Breida: Loses yardage on lone carry
Breida lost four yards on his only rushing attempt and did not catch his only target against Carolina in a 19-16 win Sunday.
Saquon Barkley again dominated running back touches for the Giants in Week 2, notching 21 carries and four catches. Breida logged 11 offensive snaps and got just one touch, which was a carry for negative yardage late in the fourth quarter. Breida has collected just six rushing attempts and one target through two weeks, emphasizing his lack of fantasy relevance barring an injury to Barkley.