Blue will serve as the Cowboys' No. 2 RB behind starter Javonte Williams moving forward after Miles Sanders (knee/ankle) was ruled out for the rest of the season, Jon Machota of The Athletic reports.

Sanders initially hurt his ankle just before halftime of Dallas' Week 4 tie with the Packers and then was listed with knee and ankle injuries ahead of being inactive this past Sunday at the Jets. A limited practice this Wednesday indicates Sanders was making a last-ditch effort to prove his health, but Executive Vice President Stephen Jones said Friday that he'll miss the remainder of the campaign. Blue made his pro debut Week 5 and turned four carries into seven yards on 11 offensive snaps, so he likely will be contained to scraps behind the workhorse that has been Williams for the foreseeable future.

Sanders (knee/ankle) will miss the rest of the season, Jon Machota of The Athletic reports.

Cowboys EVP Stephen Jones said the team is "fired up" about what Jaydon Blue can do as the No. 2 running back. The rookie had just seven yards on four touches in the first game Sanders missed, with Javonte Williams again dominating backfield work. In any case, Sanders apparently will be placed on injured reserve soon.

Spears (ankle) doesn't have an injury designation for Sunday's game against the Raiders, Jim Wyatt of the Titans' official site reports.

Spears upgraded to full participation in Friday's practice after a pair of limited sessions. After handling just four carries for 14 yards in his Week 5 season debut against the Cardinals, Spears will look to take on a larger role Sunday as the complementary option to Tony Pollard in Tennessee's backfield.

Singletary rushed three times for 10 yards and didn't log any receiving targets in Thursday's 34-17 win against Philadelphia.

Singletary continued to get a bit of work even with the return of Tyrone Tracy to New York's backfield, but neither Singletary nor Tracy did anything of note. Meanwhile, rookie Cam Skattebo continued to cement his status as the team's workhorse back with 19 carries for 98 yards and three touchdowns along with two catches for 12 yards. Skattebo was on the field for 71 percent of the Giants' offensive plays, followed by Tracy at 30 percent and Singletary at a modest six percent (four total snaps). Given that usage, it appears Singletary will fade back into the No. 3 RB role when both Skattebo and Tracy are healthy, giving the veteran very little fantasy value.

Monangai (thigh) was a full practice participant Friday.

The rookie came out of a Week 5 bye listed with a new injury, but he'll apparently be fine for Monday's game at Washington, likely filling his usual role as the No. 2 running back. Monangai took 20 touches for 85 yards over the first four weeks of the season, failing to make a move despite D'Andre Swift's mediocre results as the lead back.

Shipley saw the field for just three offensive snaps in Thursday's loss to the Giants.

Shipley hasn't been a significant part of the offense at any point this season for the Eagles, but Thursday represented his season-low snap count. He did not touch the ball on offense but did return one kick for 22 yards.

Dillon carried the ball once for two yards and caught a pair of passes for 18 yards in Thursday's loss to the Giants.

Dillon received his first two targets of the year, but overall his workload remained minimal. He's yet to receive more than three touches or see the field for more than 10 offensive snaps in a game this season.

Irving (shoulder) has been ruled out for Sunday's game against the 49ers.

Irving missed practice for a second straight week, never making a bid to play. Rachaad White figures to be tasked with workhorse usage again, while Sean Tucker will come off the bench and fourth-stringer Josh Williams (concussion) will join Irving on the inactive list. Reports last week suggested Irving was expected to miss two games, but that doesn't necessarily mean he'll be back for a Week 7 contest at Detroit on Monday Night Football (Oct. 20).

Kamara (ankle) is questionable for Sunday's game against New England, Ross Jackson of WWL Louisiana reports.

Early reports suggested Kamara hurt his ankle during Wednesday's practice, but he clarified Thursday that the injury initially occurred during a win over the Giants on Sunday. That may also explain why Kendre Miller took on so much of the rushing workload, especially late in the game. This week, Kamara was a limited practice participant Wednesday through Friday, with Mike Triplett of NewOrleans.Football suggesting that the veteran RB is on track to play. There is some risk that Kamara's workload looks more like Week 5 than Weeks 1-4, but he'll presumably still start if he's declared active ahead of the 1:00 p.m. ET kickoff.

Williams (concussion) won't play Sunday against the 49ers, Greg Auman of Fox Sports reports.

Williams was evaluated for a concussion and cleared to return during Tampa Bay's Week 5 win over the Seahawks, but he experienced concussion symptoms after Thursday's practice and was subsequently placed in concussion protocol. Despite the absence of Bucky Irving (foot/shoulder) against Seattle, Williams' contributions were limited to kickoff returns on special teams. Williams' next chance to play will come Oct. 20 against the Lions.