McCaffrey is unlikely to play in Friday's preseason finale against the Bills, though many of the Panthers other starters will suit up, David Newton of ESPN.com reports.
Coming off consecutive injury-marred seasons, McCaffrey likely will be held out of a third straight exhibition despite enjoying an injury-free summer. His absence also gives the Panthers a chance to evaluate prospective backups D'Onta Foreman and Chuba Hubbard, though neither is expected to see much work behind McCaffrey when the Panthers host the Browns in Week 1.