McCaffrey was a limited participant in practice Wednesday due to a knee injury, Eric Branch of the San Francisco Chronicle reports.
McCaffrey endured practice limitations last week with the same health concern, but he eventually ditched a designation on the final Week 13 injury report. He proceeded to have his second-most touches (25) in a 49ers uniform en route to 146 yards from scrimmage and a receiving touchdown in this past Sunday's win over the Dolphins. Assuming he gets through this week unscathed, McCaffrey will be set to dominate the backfield work Sunday versus the Buccaneers.