McCaffrey (knee) was a limited participant in Tuesday's walk-through practice, James Palmer of NFL Network reports.
McCaffrey appeared on the 49ers' practice report as a limited participant for the second day in a row, but head coach Kyle Shanahan hasn't suggested that the running back's knee irritation will cost him game action. With a quick turnaround before Thursday's matchup with Seattle, McCaffrey is likely just getting some extra rest to keep him as fresh as possible for Week 15 after he saw 16 touches in this past Sunday's win over the Buccaneers.