McCaffrey is considered day-to-day with a mild ankle sprain, Cam Inman of The San Jose Mercury News reports.
McCaffrey logged an 85 percent snap share in Sunday's 37-34 overtime win over the Raiders, while rushing 19 times for 121 yards and a TD and adding six catches on nine targets for 72 yards. However, now that 49ers' top back is dealing with an injury concern, his status will need to be monitored ahead of this weekend's contest against the Cardinals. In any case, it's a good bet that McCaffrey's practice participation in the coming days will be impacted by his current ankle issue.