The Cubs designated Woodford for assignment Tuesday, Jared Wyllys of AllCHGO.com reports.
Woodford will cede his spot on the roster to right-hander Ryan Zeferjahn, who was acquired from the Angels on Monday. A journeyman at this stage of his career, Woodford has pitched to a 7.18 ERA, 1.79 WHIP and 23:7 K:BB across 26.1 innings in the majors with the Brewers and Cubs this season.