The Texans placed Winfree (undisclosed) on injured reserve Tuesday.
Winfree signed with the Texans on Aug. 18 and played in Saturday's preseason finale against the Lions where he logged a 26-yard catch on his lone target. The nature and severity of his injury aren't clear, but by being placed on IR without a designation to return, Winfree will be forced to miss the entire 2025 season unless he reaches an injury settlement with Houston.