Mixon (ankle) is not in line to play Sunday against the Jaguars, Adam Schefter of ESPN reports.
Mixon was listed as questionable for the contest, with his Week 4 status slated to be officially confirmed once the Texans' inactives are posted ahead of Sunday's 1:00 ET kickoff. In his looming absence, Cam Akers is once again slated to lead Houston's backfield.