Harris (thigh) has been ruled out for Thursday's game against the Bills.
With Harris out, look for Rhamondre Stevenson to handle a heavy workload as New England's lead back, while Pierre Strong and Kevin Harris are on hand to work in reserve roles. The Patriots could also promote J.J. Taylor from the practice squad to add another healthy back to the mix for the Week 13 contest. Damien Harris will now target a potential return to action Week 14, when the Patriots face the Cardinals on the road on Dec. 12.