Jefferson (coach's decision) is inactive for the Lions' season opener Sunday versus the 49ers, Dave Birkett of the Detroit Free Press reports.
The rookie seventh-round pick will have to wait at least one week to make his NFL debut after the Lions elected to keep D'Andre Swift, Jamaal Williams and Godwin Igwebuike as their active running backs for Week 1. While Jefferson is more likely than Igwebuike to see snaps and touches on offense if one of Swift or Williams misses time this season, Igwebuike -- who contributes on special teams -- may end up dressing more frequently than Jefferson when all four backs are available.