Jefferson (ankle) isn't practicing Wednesday, Tim Twentyman of the Lions' official site reports.
Jefferson's absence to begin Week 11 prep was expected after he scored his first NFL touchdown and then suffered an ankle injury during Sunday's 16-16 tie with Pittsburgh. While Jefferson likely will miss this weekend's game in Cleveland, the Lions at least got Jamaal Williams (thigh) back on the practice field Wednesday, suggesting that D'Andre Swift's top backup is trending in the right direction after a two-game absence.