Williams didn't practice Wednesday due to an illness.
Williams has been the Lions' most-used running back this season, earning between 12 and 24 touches in each of the team's nine games. With nine touchdowns, he sits in a tie for third in the NFL with the Titans' Derrick Henry, but an illness now is affecting Williams' practice reps. At the same time, D'Andre Swift (ankle/shoulder) managed a full session Wednesday, so a changing of the guard in the backfield could be in store Week 11. Williams' status nonetheless will be one to watch closely as Sunday's game against the Giants approaches.