Slayton exited Sunday's contest at Cleveland due to a thumb injury, Dan Salomone of the Giants' official site reports.
At the time of his departure in the second half, Slayton had hauled in one of two targets for seven yards. The Giants' healthy and available wide receivers Sunday are Malik Nabers, Wan'Dale Robinson, Jalin Hyatt, Bryce Ford-Wheaton and Ihmir Smith-Marsette.