Edwards-Helaire (shoulder) has been ruled out for Saturday's regular-season finale against the Broncos.
Edwards-Helaire, who was inactive Week 17, was unable to practice this week, and he'll now focus on returning to Kansas City's lineup in time for the team's postseason opener. In his continued absence, Darrel Williams is slated to head the Chiefs backfield this weekend, with Derrick Gore working in a complementary role and Jerick McKinnon in reserve.