Edwards-Helaire (ankle) has been ruled out for Sunday's game against the Chargers.
Fellow running back Le'Veon Bell (knee) is listed as questionable for the contest, but with Kansas City having clinched a first-round playoff bye, depth options Darrel Williams and Darwin Thompson should both be in store for a fair share of touches regardless of Bell's status. Edwards-Helaire, meanwhile, will set his sights on being ready to play in time for the Chiefs' postseason opener Jan. 16 or 17.