Perine was not activated from the reserve/COVID-19 list and thus will not be eligible to play Sunday against the Lions.
Perine needed to be activated off the reserve/COVID-19 list Saturday in order to have a shot at playing. Instead the team opted to elevate Trayveon Williams from the practice squad with the intention of him acting as Joe Mixon's (ankle) primary backup. Perine saw a season-high 11 carries in the Week 5 loss to the Packers, but that workload was largely due to Mixon's ankle sprain and is not expected to translate to Williams with Mixon on the mend.