Perine rushed three times for seven yards in Sunday's 22-17 loss to the Jaguars.
Chase Brown carried the ball nine times for just 10 yards, and the Bengals rushed 15 times for just 23 yards as a team, with Joe Burrow scoring a rushing touchdown. Perine has rushed 13 times for 42 yards (3.2 YPC) through four games. He would need an injury to Brown to gain any fantasy relevance.