Mixon (foot) won't participate at Friday's practice, Adam Schefter of ESPN reports.
The 24-year-old is trending in the wrong direction, as he was unable to practice in any capacity this week. Mixon appears poised to miss his second straight contest, and his status will be confirmed when Cincinnati releases its injury report later Friday. Assuming he's unavailable, Giovani Bernard is in line to lead the Bengals backfield again Sunday versus the Titans.