Mixon (illness) wasn't seen warming up Thursday and will go down as a non-participant on the Bengals' official practice report, Ben Baby of ESPN.com reports.
Mixon wasn't in attendance for Wednesday's session either due to a non-COVID-19-related illness, so he'll likely need to get back on the field in some capacity Friday to avoid taking a designation into Sunday's game against the 49ers. Since the Bengals' Week 10 bye, Mixon has handled heavy workloads in each of the subsequent three contests, averaging 27 touches per game during that stretch. Samaje Perine is the next man up out of the backfield if Mixon ends up sitting out or is limited in any capacity Sunday.