The Royals optioned Spence to Triple-A Omaha on Saturday.
Spence was lit up for 10 earned runs in just 1.1 innings during Friday's 22-1 blowout loss, so the Royals will send him back to the minors in favor of Eric Cerantola. Spence has given up at least six earned runs in all three of his MLB appearances this season and owns a 6.47 ERA through 48.2 frames at Omaha.