The Royals recalled Spence from Triple-A Omaha on Friday.
With Stephen Kolek going on paternity leave and missing his scheduled start Friday against the White Sox, Spence will give the Royals' bullpen some length behind opener Steven Cruz. Spence has appeared in two games for Kansas City this season, allowing 12 runs on 11 hits and six walks with just four strikeouts across eight innings. He's operated as a starter with Omaha.