Samaniego will serve as the Red Sox's opening pitcher Friday in Cleveland, Ari Alexander of 7 News Boston reports.
Called up from Triple-A Worcester on Thursday, Samaniego is now slated for the first start of his major-league career a day later, though he'll likely be limited to an inning or two. The southpaw will be followed by Brayan Bello, who will operate in a bulk-relief role for the fourth time in five outings. Samaniego owns an impressive 1.04 ERA and 1.15 WHIP with 13 strikeouts over 17.1 frames in 18 appearances out of the bullpen with Boston this season.