Samaniego (0-3) took the loss against the Guardians on Friday, allowing four runs on six hits while striking out two over one inning as the opener.
Samaniego, who was recalled from Triple-A Worcester on Thursday, put the Red Sox in a deep hole, from which they could not dig themselves out. Ironically, he was one of Boston's most effective relievers during his first stint in the majors, recording a 1.04 ERA across 17.1 innings.