Manager Kevin Cash confirmed that Lowe (lower leg) will not return this season, Marc Topkin of the Tampa Bay Times reports.
Lowe was removed from Tuesday's rehab appearance at Triple-A Durham with a left quadriceps strain. The 25-year-old infielder was trending towards making a return to the big leagues, but his second major-league season comes to an end after posting a .276/.339/.523 triple slash in 307 plate appearances with 16 home runs, 49 RBI and 40 runs scored across just 76 games.