Weathers was recalled from Triple-A El Paso ahead of Wednesday's start against the Cubs.
The 22-year-old has struggled in the minors early in the year, posting a 7.29 ERA and 1.85 WHIP in 54.1 innings over 12 starts. However, he'll make a spot start at Wrigley Field on Wednesday with Mike Clevinger (illness) on the COVID-19 injured list. Weathers made 30 appearances (18 starts) for the Padres last year and logged a 5.32 ERA and 1.38 WHIP in 94.2 innings.