Wittgren was optioned to Triple-A New Orleans on Wednesday, Joe Frisaro of MLB.com reports.
Wittgren only appeared twice with the Marlins since being called up on April 19, but he'll head back to the minors with the Marlins needing another starting pitcher to fill out their staff. The right-hander could be back with the major league club if another injury strikes or if he impresses more in the minors. Left-hander Justin Nicolino will take his place on the 25-man roster.