Manzardo is out of the lineup for Wednesday's game against the Yankees.
With a tough lefty (Carlos Rodon) on the hill for New York, the left-handed-hitting Manzardo will get the afternoon off in the series finale. Jose Ramirez will get a day out of the infield and will serve as the Guardians' designated hitter in place of Manzardo, who has gone 6-for-19 with three home runs, two doubles, two walks, seven RBI and four runs over his last five games.