The Guardians optioned Manzardo to Triple-A Columbus on Monday, Zack Meisel of The Athletic reports.
Manzardo, who has struggled at the plate in his last 30 games, will make his first trip to Triple-A this season. This year, the 26-year-old has batted .215/.306/.378 with 13 home runs and 39 RBI in 356 plate appearances. With Cleveland's additions of Jo Adell and Nathaniel Lowe on Monday's trade deadline, Manzardo and David Fry were replaced on the active roster.